DSPP - dentin sialophosphoprotein Gene

Homo sapiens

Also known as DPP; DSP; DGI1; DMP3; DFNA39

Gene ID: 1834 | Gene type: protein coding

About DSPP

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:87,608,529-87,616,873 (from NCBI)

This gene has 1 transcript (splice variant), 71 orthologues and is associated with 10 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mutations in this gene are associated with dentinogenesis imperfecta and dentin dysplasia. This gene is present in a gene cluster on chromosome 4. Allelic differences due to repeat polymorphisms have been found for this gene. [provided by RefSeq, Jan 2016]

DSPP Products(1)

mRNA	Protein	Name
NM_014208.3	NP_055023.2	dentin sialophosphoprotein preproprotein

Protein Preferred Names

Protein Names

dentin sialophosphoprotein

deafness, autosomal dominant 39

Related Diseases

Diseases

Alias

Dentinogenesis Imperfecta 1

Capdepont Teeth	Dentinogenesis Imperfecta Type 2
Opalescent Dentin	Dentinogenesis Imperfecta Without Osteogenesis Imperfecta
Dgi-Ii	Dentinogenesis Imperfecta, Shields Type 2
DGI1	Opalescent Teeth Without Osteogenesis Imperfecta
Dentinogenesis Imperfecta, Shields Type Ii	Dgi-2
Di-2	DGI2
Dentinogenesis Imperfecta Shields Type Ii	Non-Syndromic Dentinogenesis Imperfecta
Non-Syndromic Dgi

Dentinogenesis Imperfecta, Shields Type Iii

Dentinogenesis Imperfecta Type 3	Brandywine Type Dentinogenesis Imperfecta
Dentinogenesis Imperfecta, Shields Type 3	Dgi-Iii
Dentinogenesis Imperfecta Shields Type 3	Dentinogenesis Imperfecta Type Iii
DGI3

Dentin Dysplasia, Type Ii

DTDP2	Coronal Dentin Dysplasia
Anomalous Dysplasia Of Dentin	Pulpal Dysplasia
Pulp Stones	Dentin Dysplasia, Coronal
Dd-Ii	Dentin Dysplasia Type Ii
Dentin Dysplasia, Shields Type Ii	Dentin Dyspalsia, Shields Type 2
Dentin Dysplasia 2	Dentin Dysplasia Shields Type Ii
Dysplasia, Dentin, Type 2	Dental Pulp Stone

Deafness, Autosomal Dominant 39, With Dentinogenesis Imperfecta 1

Dfna39/Dentinogenesis Imperfecta 1 Syndrome	Dfna39/Dgi1 Syndrome
Dgi1/Dfna39 Syndrome	Deafness, Autosomal Dominant 39, With Dentinogenesis
Deafness, Autosomal Dominant, 39, With Dentinogenesis Imperfecta 1	DFNA39/DGI1
Deafness, Autosomal Dominant, Type 39, With Dentinogenesis

Dentinogenesis Imperfecta

Hereditary Opalescent Dentin	Dentinogenesis Imperfecta Without Osteogenesis Imperfecta
Dgi	Capdepont Teeth
Dgi Without Oi	Di
Non-Syndromic Dgi	Non-Syndromic Dentinogenesis Imperfecta
Opalescent Teeth Without Oi	Opalescent Teeth Without Osteogenesis Imperfecta
Opalescent Dentin

Dentin Dysplasia, Type I

Radicular Dentin Dysplasia	DTDP1
Rootless Teeth	Dentin Dysplasia Type I
Dd-I	Dentin Dysplasia Shields Type I
Dentin Dysplasia, Shields Type I	Dentin Dysplasia, Type I, With Microdontia And Misshapen Teeth
Dentin Dysplasia, Type 1	Atypical Dentin Dysplasia Due To Smoc2 Deficiency
Dentin Dysplasia Type 1 With Microdontia And Shape Anomalies	Dentin Dysplasia, Radicular
Dentin Dysplasia 1	Dentin Dysplasia 1, With Extreme Microdontia And Misshapen Teeth
DTDP1-MMT	Dentin Dysplasia, Type I, With Extreme Microdontia And Misshapen Teeth
Dysplasia, Dentin, Type I

Dentin Dysplasia

Dentinal Dysplasia	Dd
Dysplasia, Dentin	Shell Teeth

Dentin Sensitivity

Sensitive Dentin

Root Caries

Cementum Caries

Dental Caries Of Root Surface

Tooth Resorption

Regional Odontodysplasia

Ghost Teeth

Odontodysplasia

Dental Pulp Necrosis

Pulp Necrosis	Necrotic Pulp
Necrosis Of The Pulp	Dead Pulp
Devitalised Pulp	Putrescent Pulpitis
Devitalized Tooth	Dental Pulp Gangrene
Pulp Gangrene	Nonvital Tooth
Pulpless Tooth	Putrescent Pulp

Dental Caries

Dental Caries Extending Into Pulp	Dental Caries Of Smooth Surface
Dental Caries Pit And Fissure	Smooth Surface Dental Caries
Dental Decay	Carious Teeth
Dental Cavity	Saprodontia
Teeth Decayed	Tooth Caries
Tooth Decay

Pulp Degeneration

Degeneration Of Dental Pulp

Periapical Periodontitis

Apical Periodontitis

Periodontitis Apical

Pulpitis

Pulp Stones

Pulpitis Nos

Root Resorption

Suppurative Periapical Periodontitis

Periapical Abscess	Apical Abscess
Suppurative Apical Periodontitis	Dentoalveolar Abscess
Dental Abscess With Sinus	Dentoalveolar Abscess With Sinus
Dental Sinus	Periapical Abscess Fistula
Apical Tooth Abscess	Apex Abscess
Dental Abscess Nos	Infection Of Tooth Nos
Abscess Of Tooth	Dental Infection Nos

Hypercementosis

Cementation Hyperplasia

Dens Evaginatus

Tooth Erosion

Generalized Erosion	Localized Erosion
Generalized Erosions	Erosion, Localized

Dental Pulp Calcification

Pulp Calcification	Pulp Calcifications
Pulpal Calcifications	Dental Pulp Stone

Gingival Recession

Localized Gingival Recession	Gingival Recession, Localized
Minimal Gingival Recession	Moderate Gingival Recession
Severe Gingival Recession	Gingival Recession, Minimal
Gingival Recession, Severe	Atrophy Of Gums
Gum Atrophy	Gingival Atrophy

Teeth, Fused

Fused Teeth

Odontoma

Dental Pulp Disease

Dental Pulp Diseases	Dental Pulp Disorder
Disorder Of Pulp Of Tooth	Pulp Disorder

Hypophosphatemia

Vitamin D-Resistant Rickets	Hereditary Hypophosphatemic Rickets
Vdrr	Vitamin D Resistant Rickets
Hypophosphatemic Rickets, X-Linked Dominant	Familial Hypophosphatemic Rickets

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Hypophosphatasia

Phosphoethanolaminuria	Childhood Hypophosphatasia
Deficiency Of Alkaline Phosphatase	Hypophospatasia, Childhood
Hypophosphatasia Mild	Phosphoethanol-Aminuria
Rathburn Disease	Hpp
Rathbun Disease	Hypophosphatasia, Childhood
Infantile Hypophosphatasia

Taurodontism

Bull Teeth

Large Pulp Chambers In The Molars

Rickets

Vitamin D Deficiency	Vitamin D
Active Rickets	Hypovitaminosis D
Nutritional Rickets	Vitamin D Deficiency Disease
Vitamin-D Deficiency Rickets	Vitamin D-Dependent Rickets
Avitaminosis D	Infantile Osteomalacia
Juvenile Osteomalacia

Brittle Bone Disorder

Osteogenesis Imperfecta	Brittle Bone Disease
Fragilitas Ossium	Osteopsathyrosis
Lobstein Disease	Oi
Vrolik Disease	Lobstein'S Disease
Lobstein'S Syndrome	Vrolik'S Disease
Porak And Durante Disease	Glass Bone Disease
Osteogenesis Imperfecta, Dominant Perinatal Lethal	Osteogenesis Imperfecta, Recessive Perinatal Lethal
Brittle Bone Syndrome	Oi - [Osteogenesis Imperfecta]
Ossium Fragility	Osteitis Fragilitans
Bony Fragility	Blue Sclera With Fragility Of Bone And Deafness
White Blue Sclera - Fragility Of Bone - Deafness

Teeth, Supernumerary

Supernumerary Teeth

Teeth Hard Tissue Disease

Hypophosphatemic Rickets, X-Linked Recessive

Hypophosphatemic Rickets	X-Linked Recessive Hypophosphatemic Rickets
XLRHR	Hypophosphatemic Rickets Disorders
Rickets Hypophosphatemic	Rickets, Hypophosphatemic, X-Linked Recessive
Familial Hypophosphatemic Rickets

Dentin Caries

Compound Dental Caries	Dental Caries Extending Into Dentine
Dental Caries Extending Into Dentin

Autosomal Recessive Hypophosphatemic Rickets

Arhr	Hypophosphatemic Rickets, Autosomal Recessive
Autosomal Recessive Hypophosphatemic Vitamin D Refractory Rickets

Tooth Agenesis

Oligodontia	Hypodontia
Selective Tooth Agenesis	Tooth Agenesis, Selective
Familial Tooth Agenesis	Anodontia
Congenital Absence Of One Tooth

Ehlers-Danlos Syndrome, Classic Type, 1

Ehlers-Danlos Syndrome, Type I	EDSCL1
Ehlers-Danlos Syndrome Classic Type 1	Ehlers-Danlos Syndrome Type 1
Ehlers-Danlos Syndrome, Type I, Formerly	Eds1, Formerly
Ehlers-Danlos Syndrome, Severe Classic Type, Formerly	Eds I, Formerly
Ehlers-Danlos Syndrome, Gravis Type, Formerly	Ehlers-Danlos Syndrome, Type 1
Type I Ehlers-Danlos Syndrome	Eds1
Eds I	Ehlers-Danlos Syndrome, Gravis Type
Ehlers-Danlos Syndrome, Severe Classic Type	Ehlers-Danlos Syndrome 1
Ehlers-Danlos, Classic Syndrome, Type 1	Ehlers-Danlos Syndrome Type 2

Geotrichosis

Osteogenesis Imperfecta, Type Iv

Osteogenesis Imperfecta Type 4	Osteogenesis Imperfecta Type Iv
OI4	Oi, Type Iv
Osteogenesis Imperfecta With Normal Sclerae	Oi Type Iv
Oi Type 4	Osteogenesis Imperfecta With Normal Sclera
Common Variable Oi With Normal Sclerae	Osteogenesis Imperfecta 4
Oi-Iv

Hypophosphatemic Rickets, X-Linked Dominant

X-Linked Hypophosphatemia	Xlh
Vitamin D-Resistant Rickets, X-Linked	X-Linked Hypophosphatemic Rickets
XLHR	Hyp
Hypophosphatemic Vitamin D-Resistant Rickets	Hpdr
X-Linked Dominant Hypophosphatemic Rickets	Familial Hypophosphatemic Rickets
Hypophosphatemia, X-Linked	Hypophosphatemia, Vitamin D-Resistant Rickets
Hypophosphatemic Rickets X-Linked Dominant	X-Linked Vitamin D-Resistant Rickets
Hypophophatemia, X-Linked	Hypophophatemic Vitamin D-Resistant Rickets
Hypophosphatemia X-Linked	Vitamin D-Resistant Rickets X-Linked
Vitamin D-Resistant Rickets	Rickets, X-Linked Hypophosphatemic

Ehlers-Danlos Syndrome

Eds	Cutis Hyperelastica
Elastic Skin	Ehlers-Danlos Syndromes
Ed Syndrome	Ehlers Danlos Syndrome
Ehlers Danlos Disease	Eds - [Ehlers-Danlos Syndrome]

Osteochondrodysplasia

Skeletal Dysplasia	Chondrodystrophy
Congenital Anomaly Of Cartilage	Osteochondrodysplasias
Cartilage Development Disorder	Osteochondrodysplasia Syndrome
Dysplasia, Skeletal	Mucopolysaccharidosis Iv

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04027	DSPP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DSPP	MGD	MGI:109172
Felis catus	DSPP	VGNC	VGNC:78482
Bos taurus	DSPP	VGNC	VGNC:106717
Rattus norvegicus	DSPP	RGD	RGD:2525