2. Gene
  3. Pikfyve - phosphoinositide kinase, FYVE type zinc finger containing Gene

Pikfyve - phosphoinositide kinase, FYVE type zinc finger containing Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as p235; Pip5k; Pip5k3; Pipk5k3; PipkIII; 5230400C17Rik

Gene ID: 18711 | Gene type: protein coding

About Pikfyve

Chromosome 1: 65,225,842-65,317,854 forward strand.GRCm39:CM000994.3

This gene has 11 transcripts (splice variants), 205 orthologues, 13 paralogues and is associated with 46 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 3.4), CNS E18 (RPKM 3.3) and 28 other tissues.

Summary

Enables phosphotransferase activity, alcohol group as acceptor and zinc ion binding activity. Involved in several processes, including neutrophil chemotaxis; phosphatidylinositol metabolic process; and vesicle organization. Acts upstream of or within myelin assembly. Located in several cellular components, including cell-cell junction; perinuclear region of cytoplasm; and vesicle membrane. Is expressed in brain; genitourinary system; integumental system; limb; and skeleton. Used to study Crohn's disease. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Orthologous to human PIKfyve (phosphoinositide kinase, FYVE-type zinc finger containing). [provided by Alliance of Genome Resources, Apr 2022]

Pikfyve Products(2)

mRNA Protein Name
NM_001310624.1 NP_001297553.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform 1
NM_011086.2 NP_035216.2 1-phosphatidylinositol 3-phosphate 5-kinase isoform 2

Pikfyve Protein Structure

FYVE_PIKfyve_Fab1

FYVE_PIKfyve_Fab1: cd15725 (153 - 214)

DEP_PIKfyve

DEP_PIKfyve: cd04448 (356 - 437)

Fab1_TCP

Fab1_TCP: cd03334 (616 - 876)

PIPKc_PIKfyve

PIPKc_PIKfyve: cd17300 (1816 - 2082)

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  • 2000
  • 2097 a.a.
Protein Preferred Names Protein Names

1-phosphatidylinositol 3-phosphate 5-kinase

FYVE finger-containing phosphoinositide kinase

PIPkin-III

PtdIns(4)P-5-kinase

phosphatidylinositol 3-phosphate 5-kinase type III

phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III

phosphatidylinositol-4-phosphate 5-kinase, type III

phosphoinositide kinase, FYVE finger containing

serine-protein kinase PIKFYVE

type III PIP kinase

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-14644 Apilimod Inhibitor 99.56% Phase 2
HY-14644A Apilimod mesylate Inhibitor 99.83% Phase 2
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13228 YM-201636 Inhibitor 98.06% Unkown
HY-118630 Vacuolin-1 Inhibitor 98.93% Unkown
HY-15982 APY0201 Inhibitor 99.93% Unkown
HY-119624 MOMIPP Inhibitor 99.37% Unkown
HY-155994 PIK5-12d Degrader 99.90% Unkown
HY-151473 PIKfyve-IN-1 Inhibitor 99.64% Unkown
HY-163133 PIKfyve-IN-3 99.55% Unkown
HY-160477 DC-SX029 Inhibitor / Unkown
HY-154956 PIKfyve-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pikfyve NCBI NCBI:200576