2. Gene
  3. Prkaca - protein kinase, cAMP dependent, catalytic, alpha Gene

Prkaca - protein kinase, cAMP dependent, catalytic, alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as PKCD; Pkaca

Gene ID: 18747 | Gene type: protein coding

About Prkaca

Chromosome 8: 84,699,622-84,723,072 forward strand.GRCm39:CM001001.3

This gene has 2 transcripts (splice variants), 288 orthologues, 4 paralogues and is associated with 10 phenotypes. Ubiquitous expression in heart adult (RPKM 86.7), subcutaneous fat pad adult (RPKM 59.9) and 28 other tissues.

Summary

This gene encodes a member of the serine/threonine protein kinase family. The holoenzyme, protein kinase A (also known as cyclic-AMP dependent protein kinase), mediates cellular response to changes in cyclic-AMP levels. This gene encodes the alpha catalytic subunit of protein kinase A. Protein kinase A-mediated signaling is transduced via phosphorylation of target proteins, and is important for many cellular functions, including mammalian sperm maturation and motility. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Apr 2013]

Prkaca Products(2)

mRNA Protein Name
NM_001277898.1 NP_001264827.1 cAMP-dependent protein kinase catalytic subunit alpha isoform 2
NM_008854.5 NP_032880.1 cAMP-dependent protein kinase catalytic subunit alpha isoform 1

Prkaca Protein Structure

STKc_PKA

STKc_PKA: cd14209 (41 - 330)

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  • 351 a.a.
Protein Preferred Names Protein Names

cAMP-dependent protein kinase catalytic subunit alpha

PKA C-alpha

sperm cAMP-dependent protein kinase catalytic subunit

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-150076 BLU2864 Inhibitor 99.24% Unkown
HY-153967 BLU0588 Inhibitor 95.92% Unkown
HY-150072 DS89002333 Inhibitor 99.87% Unkown
HY-150072B (R)-DS89002333 98.74% Unkown
HY-150072A (2S,4R)-DS89002333 / Unkown
HY-150073 DS01080522 Inhibitor / Unkown
HY-RS11104 PRKACA Human Pre-designed siRNA Set A / Unkown
HY-RS11105 Prkaca Mouse Pre-designed siRNA Set A / Unkown
HY-RS11106 Prkaca Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkaca NCBI NCBI:5566
Canis familiaris Prkaca NCBI NCBI:403556