E4F1 - E4F transcription factor 1 Gene

Homo sapiens

Also known as E4F

Gene ID: 1877 | Gene type: protein coding

About E4F1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,223,591-2,235,742 (from NCBI)

This gene has 9 transcripts (splice variants), 191 orthologues and 38 paralogues. Ubiquitous expression in spleen (RPKM 6.6), prostate (RPKM 5.8) and 25 other tissues.

Summary

The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014]

E4F1 Products(3)

mRNA	Protein	Name
NM_001288776.2	NP_001275705.2	transcription factor E4F1 isoform 2
NM_001288778.2	NP_001275707.2	transcription factor E4F1 isoform 3
NM_004424.5	NP_004415.4	transcription factor E4F1 isoform 1

E4F1 Protein Structure

zf-C2H2_6

zf-C2H2

zf-H2C2_2

0
200
400
600
784 a.a.

Protein Preferred Names

Protein Names

transcription factor E4F1

RING-type E3 ubiquitin transferase E4F1

Related Diseases

Diseases

Alias

Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations

Severe Congenital Encephalopathy Due To Mecp2 Mutation	Severe Neonatal-Onset Encephalopathy With Microcephaly
Encephalopathy, Neonatal Severe	Neonatal Severe Encephalopathy Due To Mecp2 Mutations
Mecp2-Related Severe Neonatal Encephalopathy	Methyl-Cytosine Phosphate Guanine Binding Protein 2 Related Severe Neonatal Encephalopathy
Severe Neonatal Encephalopathy Due To Mecp2 Mutations	ENS-MECP2
Encephalopathy, Neonatal, Severe

Renal Artery Obstruction

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04118	E4F1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	E4F1	RGD	RGD:1596731
Bos taurus	E4F1	VGNC	VGNC:28293
Macaca mulatta	E4F1	VGNC	VGNC:72028
Felis catus	E4F1	VGNC	VGNC:80566
Mus musculus	E4F1	MGD	MGI:109530

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