2. Gene
  3. Plk1 - polo like kinase 1 Gene

Plk1 - polo like kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Plk; STPK13

Gene ID: 18817 | Gene type: protein coding

About Plk1

Chromosome 7: 121,758,662-121,769,096 forward strand.GRCm39:CM001000.3

This gene has 3 transcripts (splice variants), 186 orthologues, 4 paralogues and is associated with 16 phenotypes. Broad expression in liver E14.5 (RPKM 39.9), liver E14 (RPKM 38.7) and 17 other tissues.

Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and may play a role in DNA replication during S phase. This gene is expressed in all embryonic tissues, but restricted to thymus and ovaries in adult tissues. Homozygous knockout mice were embryonic lethal, suggesting that this gene is important for early embryonic development. This gene is thought to be a potential oncogene because it is overexpressed in a variety of tumors and tumor cell lines. Depletion of this protein in Cancer cells has been shown to inhibit cell proliferation and suppress oncogenic transformation; hence, it is a target for Cancer therapy. [provided by RefSeq, Sep 2015]

Plk1 Products(1)

mRNA Protein Name
NM_011121.4 NP_035251.3 serine/threonine-protein kinase PLK1

Plk1 Protein Structure

STKc_PLK1

STKc_PLK1: cd14187 (44 - 308)

POLO_box_1

POLO_box_1: cd13118 (406 - 493)

POLO_box_2

POLO_box_2: cd13117 (508 - 589)

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  • 603 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PLK1

PLK-1

serine/threonine-protein kinase 13

Recombinant Plk1 Proteins

Cat. No. Product Name Accession Purity
HY-P73706 PLK1 Protein, Mouse (sf9, His) Q07832 (M1-S603) ≥95%

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12137 Volasertib Inhibitor 99.41% Yes
HY-12137A Volasertib trihydrochloride Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-12037A Rigosertib Inhibitor 98.35% Phase 3
HY-12037 Rigosertib sodium Inhibitor 99.57% Phase 3
HY-50698 BI 2536 Inhibitor 99.95% Phase 2
HY-15828 Onvansertib Inhibitor 99.55% Phase 2
HY-147298 Plogosertib Inhibitor 99.95% Phase 2
HY-50877 GSK461364 Inhibitor 99.82% Phase 1
HY-15160 TAK-960 Inhibitor 99.75% Phase 1
HY-15160B TAK-960 dihydrochloride Inhibitor 99.19% Phase 1
HY-15160A TAK-960 hydrochloride Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (23)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100789 ON1231320 Inhibitor 99.24% Unkown
HY-11003 GW843682X Inhibitor 99.75% Unkown
HY-15161 Ro3280 Inhibitor 98.87% Unkown
HY-18009 (Z)-LFM-A13 Inhibitor 99.97% Unkown
HY-15155 MLN0905 Inhibitor 99.94% Unkown
HY-108597 TC-S 7005 Inhibitor 99.56% Unkown
HY-12045 HMN-214 Inhibitor 99.25% Unkown
HY-12134 Poloxin Inhibitor 98.01% Unkown
HY-15158 SBE13 Hydrochloride Inhibitor 99.66% Unkown
HY-15159 Cyclapolin 9 Inhibitor 99.16% Unkown
HY-N8692 Dihydrobaicalein Inhibitor 99.94% Unkown
HY-160558 PLK1/BRD4-IN-3 Inhibitor / Unkown
HY-110002 LFM-A13 Inhibitor / Unkown
HY-15158A SBE13 Inhibitor / Unkown
HY-77195 Poloxime Inhibitor ≥95.0% Unkown
HY-143471 PLK1/BRD4-IN-1 Inhibitor / Unkown
HY-161521 PLK1-IN-10 Inhibitor / Unkown
HY-148974 PLK1-IN-5 Inhibitor / Unkown
HY-115589 YLT-11 Inhibitor / Unkown
HY-158031 PLK1/BRD4-IN-5 Inhibitor / Unkown
HY-18651 (E/Z)-Rigosertib sodium / Unkown
HY-149100 PLK1-IN-6 Inhibitor / Unkown
HY-112395 BTO-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plk1 NCBI NCBI:5347