2. Gene
  3. EEF1D - eukaryotic translation elongation factor 1 delta Gene

EEF1D - eukaryotic translation elongation factor 1 delta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EF1D; EF-1D; FP1047

Gene ID: 1936 | Gene type: protein coding

About EEF1D

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,579,728-143,597,415 (from NCBI)

This gene has 54 transcripts (splice variants), 1 gene allele, 266 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 42.9), spleen (RPKM 28.8) and 25 other tissues.

Summary

This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 Infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of Viral Proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]

EEF1D Products(10)

mRNA Protein Name
NM_001130053.5 NP_001123525.3 elongation factor 1-delta isoform 1
NM_001130055.4 NP_001123527.1 elongation factor 1-delta isoform 2
NM_001130056.5 NP_001123528.1 elongation factor 1-delta isoform 4
NM_001130057.4 NP_001123529.1 elongation factor 1-delta isoform 2
NM_001195203.4 NP_001182132.1 elongation factor 1-delta isoform 5
NM_001289950.4 NP_001276879.1 elongation factor 1-delta isoform 2
NM_001317743.4 NP_001304672.1 elongation factor 1-delta isoform 4
NM_001330646.3 NP_001317575.1 elongation factor 1-delta isoform 4
NM_001960.7 NP_001951.2 elongation factor 1-delta isoform 2
NM_032378.7 NP_115754.4 elongation factor 1-delta isoform 1

EEF1D Protein Structure

EF-1_beta_acid

EF-1_beta_acid: Eukaryotic elongation factor 1 beta central acidic region (159 - 186)

EF1_GNE

EF1_GNE: EF-1 guanine nucleotide exchange domain (195 - 281)

  • 0
  • 100
  • 200
  • 281 a.a.
Protein Preferred Names Protein Names

elongation factor 1-delta

EF-1-delta

Related Diseases

Diseases Alias
Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive

Autosomal Recessive Mental Retardation

Autosomal Recessive Non-Syndromic Mental Retardation

Autosomal Recessive Non-Syndromic Intellectual Disability
Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04177 EEF1D Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus EEF1D VGNC VGNC:81649
Bos taurus EEF1D VGNC VGNC:53861
Rattus norvegicus EEF1D RGD RGD:621174
Canis familiaris EEF1D VGNC VGNC:40208
Mus musculus EEF1D MGD MGI:1913906