EEF2 - eukaryotic translation elongation factor 2 Gene

Homo sapiens

Also known as EF2; EF-2; EEF-2; SCA26

Gene ID: 1938 | Gene type: protein coding

About EEF2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,976,056-3,985,463 (from NCBI)

This gene has 7 transcripts (splice variants), 222 orthologues, 18 paralogues and is associated with 3 phenotypes. Ubiquitous expression in ovary (RPKM 918.2), thyroid (RPKM 609.1) and 25 other tissues.

Summary

This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]

EEF2 Products(1)

mRNA	Protein	Name
NM_001961.4	NP_001952.1	elongation factor 2

EEF2 Protein Structure

GTP_EFTU

GTP_EFTU_D2

EFG_II

EFG_IV

EFG_C

0
200
400
600
800
858 a.a.

Protein Preferred Names

Protein Names

elongation factor 2

epididymis secretory sperm binding protein

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 26

Spinocerebellar Ataxia Type 26	SCA26
Ataxia, Spinocerebellar, Type 26

Diphtheria

Corynebacterium Infections	Corynebacterium Infection
Diphtherial Infection	Infection Due To Corynebacterium Diphtheriae

Refractory Hairy Cell Leukemia

Refractory Hematologic Cancer

Refractory Hematologic Malignancy

Fusariosis

Fusarium Infection

Retinal Melanoma

Malignant Retinal Melanoma

Malignant Melanoma Of Retina

Cerebellar Ataxia Type 41

Sca41

Myopathy, Tubular Aggregate, 1

Tubular Aggregate Myopathy	Tam
Myopathy With Tubular Aggregates	TAM1
Myopathy, Tubular Aggregate	Tubular Aggregate Myopathy 1

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-117684	Cabamiquine	Inhibitor	99.93%	Phase 2
HY-117684A	Cabamiquine succinate	Inhibitor	99.99%	Phase 2

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100576	NH125	Inhibitor	99.81%	Unkown
HY-110096	A-484954	Inhibitor	98.18%	Unkown
HY-126396	Sordarin sodium	Inhibitor	≥99.0%	Unkown
HY-120904	AMPK-IN-1	Activator	/	Unkown
HY-121828	TX-1123	Inhibitor	/	Unkown
HY-123024	Cefatrizine		/	Unkown
HY-146324	PROTAC eEF2K degrader-1		/	Unkown
HY-RS04180	EEF2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS04181	EEF2K Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EEF2	RGD	RGD:61979
Canis familiaris	EEF2	VGNC	VGNC:40209
Mus musculus	EEF2	MGD	MGI:95288
Bos taurus	EEF2	VGNC	VGNC:28335
Felis catus	EEF2	VGNC	VGNC:78444
Macaca mulatta	EEF2	VGNC	VGNC:97763
Others	EEF2	NCBI

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