2. Gene
  3. DNAH10 - dynein axonemal heavy chain 10 Gene

DNAH10 - dynein axonemal heavy chain 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SPGF56

Gene ID: 196385 | Gene type: protein coding

About DNAH10

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:123,762,301-123,935,720 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 238 orthologues, 15 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 3.1), bone marrow (RPKM 0.9) and 3 other tissues.

Summary

Dyneins are microtubule-associated motor protein complexes composed of several heavy, LIGHT, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH10 is an inner arm dynein heavy chain (Maiti et al., 2000 [PubMed 11175280]).[supplied by OMIM, Mar 2008]

DNAH10 Products(2)

mRNA Protein Name
NM_001372106.1 NP_001359035.1 dynein axonemal heavy chain 10 isoform 3
NM_207437.3 NP_997320.2 dynein axonemal heavy chain 10 isoform 1

DNAH10 Protein Structure

DHC_N1

DHC_N1: Dynein heavy chain, N-terminal region 1 (241 - 540)

DHC_N1

DHC_N1: Dynein heavy chain, N-terminal region 1 (545 - 759)

DHC_N2

DHC_N2: Dynein heavy chain, N-terminal region 2 (1253 - 1663)

AAA_6

AAA_6: Hydrolytic ATP binding site of dynein motor region D1 (1794 - 2023)

AAA_5

AAA_5: AAA domain (dynein-related subfamily) (2110 - 2244)

AAA_7

AAA_7: P-loop containing dynein motor region D3 (2420 - 2686)

AAA_8

AAA_8: P-loop containing dynein motor region D4 (2766 - 3033)

MT

MT: Microtubule-binding stalk of dynein motor (3046 - 3379)

AAA_9

AAA_9: ATP-binding dynein motor region D5 (3398 - 3628)

Dynein_heavy

Dynein_heavy: Dynein heavy chain and region D6 of dynein motor (3761 - 4468)

  • 0
  • 700
  • 1400
  • 2100
  • 2800
  • 3500
  • 4200
  • 4471 a.a.
Protein Preferred Names Protein Names

dynein axonemal heavy chain 10

axonemal beta dynein heavy chain 10

Related Diseases

Diseases Alias
Spermatogenic Failure 56

SPGF56
Spermatogenic Failure 5

Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa

Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna

SPGF5

Macrocephalic Sperm Head Syndrome

Male Infertility Due To Macrozoospermia

Infertility Associated With Multitailed Spermatozoa And Excessive Dna

Macrozoospermia

Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa

Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid

Large-Headed Multiflagellar Polyploid Spermatozoa

Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Lipodystrophy, Familial Partial, Type 1

FPLD1

Familial Partial Lipodystrophy Type 1

Familial Partial Lipodystrophy, Kobberling Type

Lipodystrophy, Familial Partial, Kobberling Type

Familial Partial Lipodystrophy Kobberling Type

Familial Partial Lipodystrophy Type Köbberling

Familial Partial Lipodystrophy, Köbberling Type

Familial Partial Lipodystrophy, Type 1
Congenital Anomalies Of Kidney And Urinary Tract Syndrome With Or Without Hearing Loss, Abnormal Ears, Or Developmental Delay

CAKUTHED

Doid:0112359

Anomalies, Congenital, Kidney And Urinary Tract Syndrome With/Without Hearing Loss, Abnormal Ears, Or Developmental Delay
Infertility
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Chronic Purulent Otitis Media

Chronic Suppurative Otitis Media

Csom - [Chronic Suppurative Otitis Media]
Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03843 DNAH10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DNAH10 VGNC VGNC:61542
Canis familiaris DNAH10 VGNC VGNC:40012
Mus musculus DNAH10 MGD MGI:1860299
Bos taurus DNAH10 VGNC VGNC:28123
Rattus norvegicus DNAH10 RGD RGD:619988