DTX3 - deltex E3 ubiquitin ligase 3 Gene

Homo sapiens

Also known as RNF154; deltex3

Gene ID: 196403 | Gene type: protein coding

About DTX3

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,604,824-57,609,802 (from NCBI)

This gene has 9 transcripts (splice variants), 183 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 21.6), endometrium (RPKM 16.7) and 24 other tissues.

Summary

DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

DTX3 Products(3)

mRNA	Protein	Name
NM_001286245.2	NP_001273174.1	probable E3 ubiquitin-protein ligase DTX3 isoform b
NM_001286246.2	NP_001273175.1	probable E3 ubiquitin-protein ligase DTX3 isoform a
NM_178502.4	NP_848597.1	probable E3 ubiquitin-protein ligase DTX3 isoform a

DTX3 Protein Structure

zf-RING_2

0
100
200
300
347 a.a.

Protein Preferred Names

Protein Names

probable E3 ubiquitin-protein ligase DTX3

RING finger protein 154

Related Diseases

Diseases

Alias

Cutaneous Diphtheria

Diphtheria Wound Infection

Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation	Intracranial Arteriovenous Malformation
Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To	Intracranial Arteriovenous Malformations
Bavm	Cerebral Arteriovenous Malformations
Intracranial Hemorrhage In Brain Cerebrovascular Malformations	Arteriovenous Malformation Of The Brain, Somatic
Intracranial Avm	Arteriovenous Malformations Cerebral

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04040	DTX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04041	DTX3L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DTX3	VGNC	VGNC:28238
Mus musculus	DTX3	MGD	MGI:2135752
Rattus norvegicus	DTX3	RGD	RGD:1566181
Canis familiaris	DTX3	VGNC	VGNC:40117
Macaca mulatta	DTX3	VGNC	VGNC:71896
Felis catus	DTX3	VGNC	VGNC:61650
Others	DTX3	NCBI

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