ADCY4 - adenylate cyclase 4 Gene

Homo sapiens

Also known as AC4

Gene ID: 196883 | Gene type: protein coding

About ADCY4

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,318,359-24,335,071 (from NCBI)

This gene has 19 transcripts (splice variants), 1 gene allele, 181 orthologues and 17 paralogues. Broad expression in placenta (RPKM 14.4), fat (RPKM 11.6) and 23 other tissues.

Summary

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that Adenylate Cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

ADCY4 Products(3)

mRNA	Protein	Name
NM_001198568.2	NP_001185497.1	adenylate cyclase type 4
NM_001198592.2	NP_001185521.1	adenylate cyclase type 4
NM_139247.4	NP_640340.2	adenylate cyclase type 4

ADCY4 Protein Structure

Guanylate_cyc

DUF1053

Guanylate_cyc

0
200
400
600
800
1000
1077 a.a.

Protein Preferred Names

Protein Names

adenylate cyclase type 4

ATP pyrophosphate-lyase 4

Related Diseases

Diseases

Alias

Amelogenesis Imperfecta, Type Iiic

AI3C	Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Recessive
Amelogenesis Imperfecta Type 3c	Amelogenesis Imperfecta, Type 3c
Amelogenesis Imperfecta Type Iiic	Autosomal Recessive Amelogenesis Imperfecta Hypocalcification Type
Amelogenesis Imperfecta 3c

Angiostrongyliasis

A. Cantonensis Angiostrongyliasis

Eosinophilic Meningitis

Eosinophilic Meningoencephalitis Due To Angiostrongylus Cantonensis

Gnathomiasis

Gnathostomiasis	Infectious Disease By Gnathostoma
Gnathostomosis	Wandering Swelling

Amelogenesis Imperfecta, Type Iv

AI4	Aihht
Amelogenesis Imperfecta Type 4	Hypomaturation-Hypoplastic Amelogenesis Imperfecta With Taurodontism
Amelogenesis Imperfecta, Hypomaturation-Hypoplastic Type, With Taurodontism	Amelogenesis Imperfecta Hypomaturation-Hypoplastic Type With Taurodontism
Amelogenesis Imperfecta 4	Ait
Amelogenesis Imperfecta 2 Hypocalcification Type	Amelogenesis Imperfecta Hypomineralization Type
Amelogenesis Imperfecta Type Iv	Amelogenesis Imperfecta With Taurodontism

Chronic Meningitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00330	ADCY4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ADCY4	VGNC	VGNC:110581
Mus musculus	ADCY4	MGD	MGI:99674
Bos taurus	ADCY4	VGNC	VGNC:25645
Rattus norvegicus	ADCY4	RGD	RGD:2034
Felis catus	ADCY4	VGNC	VGNC:59617
Canis familiaris	ADCY4	VGNC	VGNC:37621

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