LCTL - lactase like Gene

Homo sapiens

Also known as KLG; KLPH

Gene ID: 197021 | Gene type: protein coding

About LCTL

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:66,547,532-66,565,998 (from NCBI)

This gene has 8 transcripts (splice variants), 249 orthologues and 4 paralogues. Broad expression in testis (RPKM 4.1), lymph node (RPKM 0.7) and 20 other tissues.

Summary

This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

LCTL Products(4)

mRNA	Protein	Name
NM_001278562.3	NP_001265491.1	lactase-like protein isoform 2
NM_001394632.1	NP_001381561.1	lactase-like protein isoform 3
NM_001394633.1	NP_001381562.1	lactase-like protein isoform 4
NM_207338.4	NP_997221.2	lactase-like protein isoform 1 precursor

LCTL Protein Structure

Glyco_hydro_1

0
100
200
300
400
500
567 a.a.

Protein Preferred Names

Protein Names

lactase-like protein

KL lactase phlorizin hydrolase

Related Diseases

Diseases

Alias

Metacarpal 4-5 Fusion

Syndactyly Type 8	MF4
Fusion Of Metacarpals 4 And 5	Metacarpals 4 And 5 Fusion
Metacarpal 4 5 Fusion

Presbyopia

Subnormal Accommodation

Accommodation Insufficiency Of Old Age

Brooke-Spiegler Syndrome

Cyld Cutaneous Syndrome	Spiegler-Brooke Syndrome
Familial Cylindromatosis	BRSS
Bss	Sbs
Multiple Familial Trichoepithelioma	Ancell-Spiegler Cylindromas
Familial Multiple Trichoepithelioma	Trichoepithelioma
Fc	Mft
Multiple Familial Trichoepitheliomas	Ccs
Turban Tumor Syndrome	Schilbach-Rott Syndrome
Eccrine Dermal Cylindroma	Familial Multiple Trichoepitheliomata

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07566	LCTL Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LCTL	VGNC	VGNC:74049
Rattus norvegicus	LCTL	RGD	RGD:1305177
Bos taurus	LCTL	VGNC	VGNC:30820
Mus musculus	LCTL	MGD	MGI:2183549
Canis familiaris	LCTL	VGNC	VGNC:58312
Felis catus	LCTL	VGNC	VGNC:63206