2. Gene
  3. MLKL - mixed lineage kinase domain like pseudokinase Gene

MLKL - mixed lineage kinase domain like pseudokinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as hMLKL

Gene ID: 197259 | Gene type: protein coding

About MLKL

Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:74,671,855-74,700,862 (from NCBI)

This gene has 8 transcripts (splice variants), 178 orthologues and 23 paralogues. Broad expression in spleen (RPKM 10.5), bone marrow (RPKM 10.4) and 23 other tissues.

Summary

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced Necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in Necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]

MLKL Products(2)

mRNA Protein Name
NM_001142497.3 NP_001135969.1 mixed lineage kinase domain-like protein isoform 2
NM_152649.4 NP_689862.1 mixed lineage kinase domain-like protein isoform 1

MLKL Protein Structure

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (219 - 466)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 471 a.a.
Protein Preferred Names Protein Names

mixed lineage kinase domain-like protein

Recombinant MLKL Proteins

Cat. No. Product Name Accession Purity
HY-P71846 MLKL Protein, Human (P.pastoris, His) Q8NB16 (M1-K471) ≥95%

Related Diseases

Diseases Alias
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Caspase 8 Deficiency

Autoimmune Lymphoproliferative Syndrome Type 2b

Caspase-8 Deficiency

Ceds

Alps2b

Autoimmune Lymphoproliferative Syndrome, Type Iib

Alps With Recurrent Viral Infections

Autoimmune Lymphoproliferative Syndrome With Recurrent Viral Infections

Caspase 8 Deficiency Syndrome

Caspase 8 Lymphadenopathy Syndrome

Autoimmune Lymphoproliferative Syndrome Type Iib

Caspase Eight Deficiency State

CASP8D
Autoimmune Lymphoproliferative Syndrome

ALPS

Canale-Smith Syndrome

Autoimmune Lymphoproliferative Syndrome, Type Ia

Autoimmune Lymphoproliferative Syndrome, Type Ib

Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant

Css

Autoimmune Lymphoproliferative Syndrome, Type 1b

Autoimmune Lymphoproliferative Syndrome, Type 1a

Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant

Fas Deficiency

Autoimmune Lymphoproliferative Syndrome 1a

ALPS1A

Autoimmune Lymphoproliferative Syndrome Type Ia

Autoimmune Lymphoproliferative Syndrome 1b

ALPS1B

Autoimmune Lymphoproliferative Syndrome Type Ib
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (25)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100573 Necrosulfonamide Inhibitor 98.84% Unkown
HY-10587 BIX-01294 98.75% Unkown
HY-112292 GW806742X Inhibitor 99.91% Unkown
HY-144828 RIP1/RIP3/MLKL activator 1 ≥97.0% Unkown
HY-112292A GW806742X hydrochloride Inhibitor 98.77% Unkown
HY-101524 TC13172 Inhibitor 98.93% Unkown
HY-148365 NecroIr1 98.02% Unkown
HY-148366 NecroIr2 98.99% Unkown
HY-141889 MLKL-IN-2 Inhibitor 99.83% Unkown
HY-100573A (E/Z)-Necrosulfonamide Inhibitor 98.84% Unkown
HY-100573S Necrosulfonamide-d4 Inhibitor 99.26% Unkown
HY-108239 BIX-01294 trihydrochloride / Unkown
HY-139878 MLKL-IN-1 Inhibitor / Unkown
HY-148767 MLKL-IN-5 Inhibitor / Unkown
HY-149052 SZM-1209 Inhibitor / Unkown
HY-149393 RIPK3-IN-3 Inhibitor / Unkown
HY-151541 MLKL-IN-3 Inhibitor / Unkown
HY-156119 MLKL-IN-6 Inhibitor / Unkown
HY-156591 PROTAC MLKL Degrader-1 Degrader / Unkown
HY-161361 MLKL-IN-7 Inhibitor / Unkown
HY-162424 ZBP1/RIP3/MLKL activator 1 Activator / Unkown
HY-RS08492 MLKL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-151542 MLKL-IN-4 Inhibitor / Unkown
HY-157039 RIPK1-IN-17 Inhibitor / Unkown
HY-N8380 (-)-Latifolin / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MLKL RGD RGD:1592221
Mus musculus MLKL MGD MGI:1921818
Bos taurus MLKL VGNC VGNC:31500
Macaca mulatta MLKL VGNC VGNC:82188
Others MLKL NCBI