EIF4A2 - eukaryotic translation initiation factor 4A2 Gene

Homo sapiens

Also known as DDX2B; EIF4A; EIF4F; BM-010; eIF4A-II; eIF-4A-II

Gene ID: 1974 | Gene type: protein coding

About EIF4A2

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,783,577-186,789,897 (from NCBI)

This gene has 27 transcripts (splice variants), 230 orthologues, 38 paralogues and is associated with 54 phenotypes. Ubiquitous expression in ovary (RPKM 426.9), brain (RPKM 313.7) and 25 other tissues.

Summary

Enables ATP hydrolysis activity. Involved in negative regulation of RNA-directed 5'-3' RNA polymerase activity. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

EIF4A2 Products(1)

mRNA	Protein	Name
NM_001967.4	NP_001958.2	eukaryotic initiation factor 4A-II

EIF4A2 Protein Structure

DEAD

Helicase_C

0
100
200
300
408 a.a.

Protein Preferred Names

Protein Names

eukaryotic initiation factor 4A-II

ATP-dependent RNA helicase eIF4A-2

Recombinant EIF4A2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700526	EIF4A2 Protein, Human (GST)	Q14240 (M1-I407)	≥95%

Related Diseases

Diseases

Alias

Fragile X-Associated Tremor/Ataxia Syndrome

Fxtas Syndrome	Fragile X Tremor/Ataxia Syndrome
Fxtas

Spinocerebellar Ataxia 8

Spinocerebellar Ataxia Type 8	SCA8
Ataxia, Spinocerebellar, Type 8

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145262	eIF4E-IN-2	Inhibitor	98.76%	Unkown
HY-129768	CMLD012072	Inhibitor	/	Unkown
HY-RS04271	EIF4A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04275	EIF4E2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04278	EIF4EBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04282	EIF4G2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EIF4A2	VGNC	VGNC:84185
Canis familiaris	EIF4A2	VGNC	VGNC:40280
Mus musculus	EIF4A2	MGD	MGI:106906
Bos taurus	EIF4A2	VGNC	VGNC:28405
Felis catus	EIF4A2	VGNC	VGNC:61788
Rattus norvegicus	EIF4A2	RGD	RGD:1309225
Others	EIF4A2	NCBI

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