2. Gene
  3. Rock1 - Rho-associated coiled-coil containing protein kinase 1 Gene

Rock1 - Rho-associated coiled-coil containing protein kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Rock-I; 1110055K06Rik

Gene ID: 19877 | Gene type: protein coding

About Rock1

Chromosome 18: 10,064,401-10,182,045 reverse strand.GRCm39:CM001011.3

This gene has 8 transcripts (splice variants), 212 orthologues, 5 paralogues and is associated with 26 phenotypes. Ubiquitous expression in bladder adult (RPKM 7.8), placenta adult (RPKM 6.) and 28 other tissues.

Summary

Predicted to enable Rho-dependent protein serine/threonine kinase activity; aspartic-type endopeptidase inhibitor activity; and small GTPase binding activity. Involved in several processes, including glomerular visceral epithelial cell migration; positive regulation of focal adhesion assembly; and response to angiotensin. Acts upstream of or within several processes, including apical constriction; bleb assembly; and negative regulation of neuron apoptotic process. Located in several cellular components, including cytoplasmic stress granule; lamellipodium; and ruffle. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and skeletal muscle. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Rock1 Products(1)

mRNA Protein Name
NM_009071.2 NP_033097.1 rho-associated protein kinase 1

Rock1 Protein Structure

STKc_ROCK1

STKc_ROCK1: cd05622 (1 - 405)

Smc

Smc: cl34174 (421 - 1096)

HR1_ROCK1

HR1_ROCK1: cd11639 (488 - 553)

ROCK_SBD

ROCK_SBD: cd22250 (835 - 912)

PH_ROCK

PH_ROCK: cd01242 (1118 - 1224)

C1_ROCK1

C1_ROCK1: cd20874 (1221 - 1289)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1354 a.a.
Protein Preferred Names Protein Names

rho-associated protein kinase 1

Rho-associated coiled-coil forming kinase 1

p160 ROCK-1

p160ROCK

rho-associated, coiled-coil-containing protein kinase 1

rho-associated, coiled-coil-containing protein kinase I

Related Agents

Approval
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10341 Fasudil Hydrochloride Inhibitor 99.96% Yes
HY-15307 Belumosudil Inhibitor 99.77% Yes
HY-15685 Ripasudil Inhibitor 99.92% Unkown
HY-13911 Hydroxyfasudil Inhibitor 98.42% Unkown
HY-13911A Hydroxyfasudil hydrochloride Inhibitor 98.88% Unkown
HY-15307A Belumosudil mesylate Inhibitor 99.88% Yes
HY-10341A Fasudil Inhibitor / Unkown
HY-10341C Fasudil dihydrochloride Inhibitor / Unkown
HY-10341B Fasudil hydrochloride semihydrate Inhibitor / Unkown
HY-15685A Ripasudil free base Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-109191 Sovesudil Inhibitor 98.31% Phase 3
HY-109191A Sovesudil hydrochloride Inhibitor 99.79% Phase 3
HY-15687A SAR407899 Inhibitor 99.86% Phase 2
HY-15687 SAR407899 hydrochloride Inhibitor 98.66% Phase 2
HY-16071 AT13148 Inhibitor 99.21% Phase 1
Pre-clinical Phase
Bioactive Molecules (26)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10071 Y-27632 Inhibitor 99.97% Unkown
HY-10583 Y-27632 dihydrochloride Inhibitor 99.98% Unkown
HY-15392 Chroman 1 Inhibitor 99.48% Unkown
HY-15556 GSK269962A Inhibitor 99.83% Unkown
HY-11000 GSK429286A Inhibitor 98.15% Unkown
HY-119937 ROCK inhibitor-2 Inhibitor 99.87% Unkown
HY-15755 RKI-1447 Inhibitor 98.29% Unkown
HY-18990 GSK180736A Inhibitor 98.01% Unkown
HY-13300 SR-3677 Inhibitor 99.90% Unkown
HY-12437 BDP5290 Inhibitor 98.80% Unkown
HY-16758 Verosudil Inhibitor 99.18% Unkown
HY-14362 GSK-25 Inhibitor 99.68% Unkown
HY-108518 SB-772077B dihydrochloride Inhibitor ≥99.0% Unkown
HY-100270 Rho-Kinase-IN-1 Inhibitor 99.91% Unkown
HY-10319 BAY-549 Inhibitor 99.46% Unkown
HY-126275 HSD1590 Inhibitor 99.54% Unkown
HY-110339 RKI-1447 dihydrochloride Inhibitor 98.04% Unkown
HY-149266 THK01 Inhibitor / Unkown
HY-15392A Chroman 1 dihydrochloride Inhibitor 99.11% Unkown
HY-107209 RKI-1313 Inhibitor ≥98.0% Unkown
HY-132302A Hu7691 free base Inhibitor / Unkown
HY-132302 Hu7691 Inhibitor / Unkown
HY-14227 LIMK-IN-1 Inhibitor / Unkown
HY-122011 PF-4950834 Inhibitor / Unkown
HY-15556A GSK269962A hydrochloride Inhibitor / Unkown
HY-13300A SR-3677 dihydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rock1 NCBI NCBI:6093