HACD2 - 3-hydroxyacyl-CoA dehydratase 2 Gene

Homo sapiens

Also known as PTPLB

Gene ID: 201562 | Gene type: protein coding

About HACD2

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:123,491,554-123,585,053 (from NCBI)

This gene has 5 transcripts (splice variants), 215 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 34.0), prostate (RPKM 10.4) and 24 other tissues.

Summary

The protein encoded by this gene can catalyze the third step (dehydration) in the conversion of long chain fatty acids to very long chain fatty acids. The encoded protein localizes to the endoplasmic reticulum membrane. [provided by RefSeq, Jul 2016]

HACD2 Products(5)

mRNA	Protein	Name
NM_001329783.2	NP_001316712.1	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform a
NM_001329784.2	NP_001316713.1	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform c
NM_001329786.2	NP_001316715.1	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform d
NM_001329787.2	NP_001316716.1	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform d
NM_198402.5	NP_940684.1	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform b

HACD2 Protein Structure

PTPLA

0
100
200
254 a.a.

Protein Preferred Names

Protein Names

very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2

protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b

Related Diseases

Diseases

Alias

Unilateral Focal Polymicrogyria

Spinocerebellar Ataxia 34

Erythrokeratodermia With Ataxia	Spinocerebellar Ataxia Type 34
SCA34	Erythrokeratodermia - Ataxia
Giroux Barbeau Syndrome	Spinocerebellar Ataxia And Erythrokeratodermia
Erythrokeratodermia Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05985	HACD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HACD2	VGNC	VGNC:102753
Rattus norvegicus	HACD2	RGD	RGD:1306337
Mus musculus	HACD2	MGD	MGI:1918007
Bos taurus	HACD2	VGNC	VGNC:50252
Macaca mulatta	HACD2	VGNC	VGNC:73382
Canis familiaris	HACD2	VGNC	VGNC:53075

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