DNAH12 - dynein axonemal heavy chain 12 Gene

Homo sapiens

Also known as DHC3; DLP3; HL19; DLP12; DNHD2; HDHC3; HL-19; DNAH7L; DNAHC3; DNAH12L; DNAHC12

Gene ID: 201625 | Gene type: protein coding

About DNAH12

Cytogenetic location: 3p14.3 Genomic coordinates (GRCh38): 3:57,293,700-57,556,034 (from NCBI)

This gene has 9 transcripts (splice variants), 278 orthologues and 15 paralogues. Biased expression in testis (RPKM 1.9), lung (RPKM 0.7) and 2 other tissues.

Summary

Predicted to enable several functions, including ATP binding activity; dynein intermediate chain binding activity; and dynein LIGHT intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be located in cilium; cytoplasm; and microtubule. Predicted to be part of dynein complex. [provided by Alliance of Genome Resources, Apr 2022]

DNAH12 Products(2)

mRNA	Protein	Name
NM_001366028.2	NP_001352957.1	dynein axonemal heavy chain 12 isoform 4
NM_198564.4	NP_940966.2	dynein axonemal heavy chain 12 isoform 2

DNAH12 Protein Structure

DHC_N2

AAA_6

AAA_5

AAA_7

AAA_8

Dynein_heavy

0
500
1000
1500
2000
2500
3092 a.a.

Protein Preferred Names

Protein Names

dynein axonemal heavy chain 12

axonemal beta dynein heavy chain 12

Related Diseases

Diseases

Alias

Ciliary Dyskinesia, Primary, 3

Primary Ciliary Dyskinesia 3	CILD3
Ciliary Dyskinesia, Primary, 3, With Or Without Situs Inversus	Primary Ciliary Dyskinesia 3 With Or Without Situs Inversus
Ics3	Immotile Cilia Syndrome 3
Dyskinesia, Ciliary, Primary, 3

Sulfonamide Allergy

Papillary Craniopharyngioma

Craniopharyngioma, Papillary	Papillary Rathke'S Pouch Tumor
Craniopharyngioma Papillary

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03845	DNAH12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DNAH12	RGD	RGD:619990
Canis familiaris	DNAH12	VGNC	VGNC:81894
Mus musculus	DNAH12	MGD	MGI:107720

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