2. Gene
  3. SENP5 - SUMO specific peptidase 5 Gene

SENP5 - SUMO specific peptidase 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 205564 | Gene type: protein coding

About SENP5

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:196,867,920-196,934,714 (from NCBI)

This gene has 7 transcripts (splice variants), 158 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 8.4), brain (RPKM 6.3) and 25 other tissues.

Summary

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]

SENP5 Products(2)

mRNA Protein Name
NM_001308045.2 NP_001294974.1 sentrin-specific protease 5 isoform 2
NM_152699.5 NP_689912.2 sentrin-specific protease 5 isoform 1

SENP5 Protein Structure

Peptidase_C48

Peptidase_C48: Ulp1 protease family, C-terminal catalytic domain (581 - 752)

  • 0
  • 200
  • 400
  • 600
  • 755 a.a.
Protein Preferred Names Protein Names

sentrin-specific protease 5

SUMO1/sentrin specific peptidase 5

Related Diseases

Diseases Alias
3-Methylglutaconic Aciduria, Type Iii

Optic Atrophy

3-Methylglutaconic Aciduria Type 3

Costeff Syndrome

Mga3

Costeff Optic Atrophy Syndrome

Optic Atrophy Plus Syndrome

Infantile Optic Atrophy With Chorea And Spastic Paraplegia

3-Methylglutaconic Aciduria Type Iii

Autosomal Recessive Optic Atrophy Plus Syndrome

Autosomal Recessive Optic Atrophy Type 3

Opa3 Defect

MGCA3

Mga, Type Iii

Iraqi Jewish Optic Atrophy Plus

Mga Type Iii

Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia

Iraqi-Jewish 'Optic Atrophy Plus'

Optic Atrophy 3, Autosomal Recessive

Opa3, Autosomal Recessive

Opa3-Related 3-Methylglutaconic Aciduria

Iraqi-Jewish Optic Atrophy Plus

Atrophy Of Optic Disc

3-Alpha Methylglutaconic Aciduria Type Iii

Optic Atrophy 3

Optic Atrophy Infantile With Chorea And Spastic Paraplegia

Autosomal Recessive Opa3

Autosomal Recessive Optic Atrophy 3

3-Methylglutaconic Aciduria 3

3-Alpha-Methylglutaconic Aciduria Type 3

Optic Atrophy 3 Autosomal Recessive

Atrophy, Optic

Atrophy, Optic, Plus Syndrome

Optic Nerve Atrophy

Primary Optic Atrophy

Oa - [Optic Atrophy]

Second Cranial Nerve Atrophy

Second Cranium Nerve Atrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-151358 SENP2-IN-1 Inhibitor / Unkown
HY-RS12674 SENP5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SENP5 VGNC VGNC:34447
Macaca mulatta SENP5 VGNC VGNC:77321
Canis familiaris SENP5 VGNC VGNC:46007
Felis catus SENP5 VGNC VGNC:65003
Mus musculus SENP5 MGD MGI:2443596
Rattus norvegicus SENP5 RGD RGD:1304604
Others SENP5 NCBI