ETF1 - eukaryotic translation termination factor 1 Gene

Homo sapiens

Also known as ERF; RF1; ERF1; TB3-1; D5S1995; SUP45L1

Gene ID: 2107 | Gene type: protein coding

About ETF1

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,506,095-138,543,236 (from NCBI)

This gene has 9 transcripts (splice variants) and 246 orthologues. Ubiquitous expression in bone marrow (RPKM 46.6), esophagus (RPKM 37.2) and 25 other tissues.

Summary

This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]

ETF1 Products(6)

mRNA	Protein	Name
NM_001256302.2	NP_001243231.1	eukaryotic peptide chain release factor subunit 1 isoform 2
NM_001282185.2	NP_001269114.1	eukaryotic peptide chain release factor subunit 1 isoform 3
NM_001291974.2	NP_001278903.1	eukaryotic peptide chain release factor subunit 1 isoform 2
NM_001291975.2	NP_001278904.1	eukaryotic peptide chain release factor subunit 1 isoform 2
NM_001364160.2	NP_001351089.1	eukaryotic peptide chain release factor subunit 1 isoform 2
NM_004730.4	NP_004721.1	eukaryotic peptide chain release factor subunit 1 isoform 1

ETF1 Protein Structure

eRF1_1

eRF1_2

eRF1_3

0
100
200
300
400
437 a.a.

Protein Preferred Names

Protein Names

eukaryotic peptide chain release factor subunit 1

polypeptide chain release factor 1

Related Diseases

Diseases

Alias

Human Monocytic Ehrlichiosis

Ehrlichiosis Chafeensis	Hme
Human Ehrlichial Infection, Human Monocytic Type

Ulna And Fibula, Absence Of, With Severe Limb Deficiency

Schinzel Phocomelia Syndrome	Aarrs
Limb/Pelvis-Hypoplasia/Aplasia Syndrome	LPHAS
Schinzel Type Phocomelia	Absence Of Ulna And Fibula With Severe Limb Deficiency
Al-Awadi/Raas-Rothschild Syndrome	Al Awadi-Raas-Rothschild Syndrome
Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome	Aplasia/Hypoplasia Of Limbs And Pelvis
Congenital Absence Of Ulna And Fibula	Severe Limb Deficit
Phocomelia, Schinzel Type	Al-Awadi-Raas-Rothschild Syndrome
Ulna And Fibula Absence Of With Severe Limb Deficiency	Limb Pelvis Hypoplasia Aplasia Syndrome
Limb/Pelvis/Uterus-Hypoplasia/Aplasia Syndrome	Ulna And Fibula, Absence Of, With Sever Limb Deficiency

Bone Chondrosarcoma

Human Granulocytic Anaplasmosis

Human Granulocytic Ehrlichiosis	Hge
Human Ehrlichial Infection, Human Granulocytic Type	Human Anaplasmosis Due To Anaplasma Phagocytophilum

Ehrlichiosis

Human Ehrlichiosis	He
Hey

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04554	ETF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ETF1	VGNC	VGNC:84370
Felis catus	ETF1	VGNC	VGNC:97422
Bos taurus	ETF1	VGNC	VGNC:28617
Mus musculus	ETF1	MGD	MGI:2385071
Rattus norvegicus	ETF1	RGD	RGD:1305712

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