2. Gene
  3. Top1 - topoisomerase (DNA) I Gene

Top1 - topoisomerase (DNA) I Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Top-1; D130064I21Rik

Gene ID: 21969 | Gene type: protein coding

About Top1

Chromosome 2: 160,487,808-160,564,684 forward strand.GRCm39:CM000995.3

This gene has 6 transcripts (splice variants), 273 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in CNS E11.5 (RPKM 28.9), adrenal adult (RPKM 26.1) and 28 other tissues.

Summary

Enables DNA Topoisomerase type I (single strand cut, ATP-independent) activity. Acts upstream of or within DNA replication; DNA topological change; and embryonic cleavage. Located in cytoplasm; nucleus; and perikaryon. Is expressed in brain; cerebral cortex ventricular layer; cortical plate; and telencephalon. Orthologous to human TOP1 (DNA Topoisomerase I). [provided by Alliance of Genome Resources, Apr 2022]

Top1 Products(4)

mRNA Protein Name
NM_009408.3 NP_033434.2 DNA topoisomerase 1 isoform 1
NM_001413149.1 NP_001400078.1 DNA topoisomerase 1 isoform 3
NM_001413148.1 NP_001400077.1 DNA topoisomerase 1 isoform 2
NM_001413150.1 NP_001400079.1 DNA topoisomerase 1 isoform 4

Top1 Protein Structure

Topoisomer_IB_N_htopoI_like

Topoisomer_IB_N_htopoI_like: cd03488 (217 - 431)

TOPEUc

TOPEUc: smart00435 (361 - 738)

  • 0
  • 200
  • 400
  • 600
  • 767 a.a.
Protein Preferred Names Protein Names

DNA topoisomerase 1

DNA topoisomerase I

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16560 Camptothecin 99.82% Unkown
Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-U00248A LMP744 hydrochloride Inhibitor 99.70% Phase 1
HY-U00248 LMP744 Inhibitor 97.00% Phase 1
Pre-clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0114A (±)-Evodiamine 99.97% Unkown
HY-18350 Indimitecan Inhibitor 98.03% Unkown
HY-160005 LMP517 Inhibitor / Unkown
HY-126142 Top1 inhibitor 1 Inhibitor / Unkown
HY-143265 Topoisomerase I inhibitor 2 / Unkown
HY-144794 EGFR-IN-46 / Unkown
HY-146437 Topoisomerase I inhibitor 6 Inhibitor / Unkown
HY-149348 DiPT-4 / Unkown
HY-RS14890 TOP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14891 Top1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14892 Top1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14893 TOP1MT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-118942 Topovale Inhibitor / Unkown
HY-133219 Guajadial C Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Top1 NCBI NCBI:7150