2. Gene
  3. KIF6 - kinesin family member 6 Gene

KIF6 - kinesin family member 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as C6orf102; dJ137F1.4; dJ188D3.1; dJ1043E3.1

Gene ID: 221458 | Gene type: protein coding

About KIF6

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:39,329,990-39,725,408 (from NCBI)

This gene has 8 transcripts (splice variants), 197 orthologues and 41 paralogues. Biased expression in testis (RPKM 1.6), brain (RPKM 1.0) and 4 other tissues.

Summary

This gene encodes a member of a family of molecular motors which are involved in intracellular transport of protein complexes, membrane organelles, and messenger ribonucleic acid along microtubules. Kinesins function as homodimeric molecules with two N-terminal head domains that move along microtubules and two C-terminal tail domains that interact with the transported cargo, either directly or indirectly, through adapter molecules. This gene is ubiquitously expressed in coronary arteries and other vascular tissue. A naturally occurring mutation in this gene is associated with coronary heart disease. [provided by RefSeq, May 2017]

KIF6 Products(13)

mRNA Protein Name
XM_047418330.1 XP_047274286.1 kinesin-like protein KIF6 isoform X4
XR_001743238.2
NM_145027.6 NP_659464.3 kinesin-like protein KIF6 isoform 1
XM_047418331.1 XP_047274287.1 kinesin-like protein KIF6 isoform X6
NM_001289020.3 NP_001275949.1 kinesin-like protein KIF6 isoform 2
XM_011514361.3 XP_011512663.1 kinesin-like protein KIF6 isoform X5
NM_001289021.3 NP_001275950.1 kinesin-like protein KIF6 isoform 3
XM_011514358.4 XP_011512660.1 kinesin-like protein KIF6 isoform X3
XM_005248904.5 XP_005248961.1 kinesin-like protein KIF6 isoform X1
NM_001351503.2 NP_001338432.1 kinesin-like protein KIF6 isoform 6
NM_001289024.3 NP_001275953.1 kinesin-like protein KIF6 isoform 4
NM_001351566.2 NP_001338495.1 kinesin-like protein KIF6 isoform 5
XM_011514357.4 XP_011512659.1 kinesin-like protein KIF6 isoform X2

KIF6 Protein Structure

Kinesin

Kinesin: Kinesin motor domain (47 - 343)

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  • 814 a.a.
Protein Preferred Names Protein Names

kinesin-like protein KIF6

Related Diseases

Diseases Alias
Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Congenital Anomaly Of Heart

Heart Defect

Heart Malformation

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure
Smallpox

Variola

Ordinary Smallpox

Alastrim

Amaas
Idiopathic Scoliosis

Scoliosis Idiopathic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07292 KIF6 Human Pre-designed siRNA Set A / Unkown
HY-RS07293 Kif6 Mouse Pre-designed siRNA Set A / Unkown
HY-RS07294 Kif6 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta KIF6 VGNC VGNC:73873
Canis familiaris KIF6 VGNC VGNC:42410
Mus musculus KIF6 MGD MGI:1098238
Felis catus KIF6 VGNC VGNC:63118
Rattus norvegicus KIF6 RGD RGD:621070
Bos taurus KIF6 VGNC VGNC:106795