2. Gene
  3. LRWD1 - leucine rich repeats and WD repeat domain containing 1 Gene

LRWD1 - leucine rich repeats and WD repeat domain containing 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ORCA; CENP-33

Gene ID: 222229 | Gene type: protein coding

About LRWD1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:102,464,984-102,473,168 (from NCBI)

This gene has 9 transcripts (splice variants), 188 orthologues and 1 paralogue. Biased expression in testis (RPKM 101.1) and bone marrow (RPKM 5.9).

Summary

The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

LRWD1 Products(2)

mRNA Protein Name
NM_001317721.2 NP_001304650.1 leucine-rich repeat and WD repeat-containing protein 1 isoform 2
NM_152892.3 NP_690852.1 leucine-rich repeat and WD repeat-containing protein 1 isoform 1

LRWD1 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (48 - 102)

WD40

WD40: WD domain, G-beta repeat (384 - 421)

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  • 647 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat and WD repeat-containing protein 1

ORC-associated protein

Related Diseases

Diseases Alias
Skin Angiosarcoma

Angiosarcoma Of Skin

Hemangiosarcoma Of The Skin

Haemangiosarcoma Of Skin

Lymphangiosarcoma Of Skin

Cutaneous Angiosarcoma

Malignant Haemangioendothelioma Of Skin
Embryonal Testis Carcinoma

Testicular Embryonal Carcinoma

Embryonal Carcinoma Of Testis

Embryonal Carcinoma Of The Testis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07849 LRWD1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LRWD1 MGD MGI:1918985
Felis catus LRWD1 VGNC VGNC:63320
Macaca mulatta LRWD1 VGNC VGNC:74332
Bos taurus LRWD1 VGNC VGNC:31048
Rattus norvegicus LRWD1 RGD RGD:1359442
Canis familiaris LRWD1 VGNC VGNC:42835