ALDH9A1 - aldehyde dehydrogenase 9 family member A1 Gene

Homo sapiens

Also known as E3; ALDH4; ALDH7; ALDH9; TMABADH; TMABA-DH; TMABALDH

Gene ID: 223 | Gene type: protein coding

About ALDH9A1

Cytogenetic location: 1q24.1 Genomic coordinates (GRCh38): 1:165,662,216-165,698,562 (from NCBI)

This gene has 5 transcripts (splice variants), 219 orthologues and 17 paralogues. Ubiquitous expression in fat (RPKM 90.6), thyroid (RPKM 83.5) and 25 other tissues.

Summary

This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The Enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits. [provided by RefSeq, Jul 2008]

ALDH9A1 Products(2)

mRNA	Protein	Name
NM_000696.4	NP_000687.3	4-trimethylaminobutyraldehyde dehydrogenase isoform 1
NM_001365774.2	NP_001352703.1	4-trimethylaminobutyraldehyde dehydrogenase isoform 2

ALDH9A1 Protein Structure

Aldedh

0
100
200
300
400
518 a.a.

Protein Preferred Names

Protein Names

4-trimethylaminobutyraldehyde dehydrogenase

R-aminobutyraldehyde dehydrogenase

Related Diseases

Diseases

Alias

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Alcohol Use Disorder

Alcohol Abuse	Alcoholism
Ethanol Abuse	Alcohol Addiction
Alcohol Dependence	Alcoholic Intoxication, Chronic
Alcohol-Related Disorders

Gamma-Amino Butyric Acid Metabolism Disorder

Disorder Of Gamma-Aminobutyric Acid Metabolism	Disorder Of Gaba Metabolism
Disorders Of Gaba - [Gamma Aminobutyric Acid] Metabolism

Succinic Semialdehyde Dehydrogenase Deficiency

4-Hydroxybutyric Aciduria	Ssadh Deficiency
Gamma-Hydroxybutyric Aciduria	Gaba Metabolic Defect
SSADHD	Ssadh
Succinate-Semialdehyde Dehydrogenase Deficiency	Gamma-Hydroxybutyricaciduria
4-Hydroxybutyricaciduria	Gamma-Hydroxybutyric Acidemia
Succinate Semialdehyde Dehydrogenase Deficiency

Hyperprolinemia

Proline Oxidase Deficiency	Hyperprolinemia Type 1
Proline Hydrogenase Deficiency	Prolinemia
Pyrroline Carboxylate Dehydrogenase Deficiency	Pyrroline-5-Carboxylate Dehydrogenase Deficiency
Proline Dehydrogenase Deficiency	Hyperprolinemia Type 2

Alcoholic Hepatitis

Acute Alcoholic Hepatitis	Acute Alcoholic Liver Disease
Hepatitis, Alcoholic	Hepatitis Alcoholic
Ah - [Alcoholic Hepatitis]	Ethanol Hepatitis

Alcoholic Liver Cirrhosis

Alcoholic Cirrhosis	Portal Cirrhosis
Alcoholic Cirrhosis Of Liver	Liver Cirrhosis, Alcoholic
Laennec'S Cirrhosis	Laennec'S Cirrhosis, Alcoholic
Alcohol Cirrhosis	Alcoholic Laennec Cirrhosis
Alcoholic Cirrhosis Nos	Etoh Cirrhosis
Alcohol Hepatic Cirrhosis	Alcohol Liver Cirrhosis
Laennec Cirrhosis

Pleurisy

Sjogren-Larsson Syndrome

Sjögren-Larsson Syndrome	SLS
Faldh Deficiency	Fatty Aldehyde Dehydrogenase Deficiency
Fatty Acid Alcohol Oxidoreductase Deficiency	Ichthyosis, Spastic Neurologic Disorder, And Oligophrenia
Sjogren Larsson Syndrome	Fatty Alcohol:Nad+ Oxidoreductase Deficiency
Sjogren-Larsson'S Syndrome	Fadh Deficiency
Fao Deficiency	Congenital Icthyosis Mental Retardation Spasticity Syndrome
Ichthyosis Oligophrenia Syndrome	Sjoegren-Larsson Syndrome

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00582	ALDH9A1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ALDH9A1	VGNC	VGNC:37791
Rattus norvegicus	ALDH9A1	RGD	RGD:68409
Felis catus	ALDH9A1	VGNC	VGNC:97346
Mus musculus	ALDH9A1	MGD	MGI:1861622
Bos taurus	ALDH9A1	VGNC	VGNC:25820
Macaca mulatta	ALDH9A1	VGNC	VGNC:99842

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