2. Gene
  3. MAPK15 - mitogen-activated protein kinase 15 Gene

MAPK15 - mitogen-activated protein kinase 15 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ERK7; ERK8

Gene ID: 225689 | Gene type: protein coding

About MAPK15

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,716,349-143,722,458 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 197 orthologues and 19 paralogues. Biased expression in lung (RPKM 5.3), testis (RPKM 4.6) and 9 other tissues.

Summary

Enables MAP kinase activity and chromatin binding activity. Involved in several processes, including dopamine uptake; positive regulation of DNA metabolic process; and regulation of organelle organization. Located in several cellular components, including Golgi apparatus; autophagosome; and microtubule organizing center. Biomarker of breast Cancer. [provided by Alliance of Genome Resources, Apr 2022]

MAPK15 Products(10)

mRNA Protein Name
XM_011516927.3 XP_011515229.1 mitogen-activated protein kinase 15 isoform X3
XM_011516925.3 XP_011515227.1 mitogen-activated protein kinase 15 isoform X1
XM_047421568.1 XP_047277524.1 mitogen-activated protein kinase 15 isoform X6
XM_047421567.1 XP_047277523.1 mitogen-activated protein kinase 15 isoform X5
XR_001745493.2
XM_047421566.1 XP_047277522.1 mitogen-activated protein kinase 15 isoform X4
XM_011516928.3 XP_011515230.1 mitogen-activated protein kinase 15 isoform X7
XM_011516926.3 XP_011515228.1 mitogen-activated protein kinase 15 isoform X2
XR_001745494.2
NM_139021.3 NP_620590.2 mitogen-activated protein kinase 15

MAPK15 Protein Structure

Pkinase

Pkinase: Protein kinase domain (15 - 304)

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  • 544 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 15

ERK-7

ERK-8

MAP kinase 15

MAPK 15

extracellular regulated kinase 8 delta

extracellular signal-regulated kinase 7

extracellular signal-regulated kinase 8

Related Diseases

Diseases Alias
Hemangioma Of Subcutaneous Tissue

Angioma Of The Subcutaneous Tissue

Subcutaneous Haemangioma

Subcutaneous Hemangioma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-135906 CK2/ERK8-IN-1 ≥99.0% Unkown
HY-RS08110 MAPK15 Human Pre-designed siRNA Set A / Unkown
HY-RS08111 Mapk15 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08112 Mapk15 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MAPK15 VGNC VGNC:31217
Canis familiaris MAPK15 VGNC VGNC:42996
Macaca mulatta MAPK15 VGNC VGNC:74570
Mus musculus MAPK15 MGD MGI:2652894
Rattus norvegicus MAPK15 RGD RGD:628675