2. Gene
  3. P2rx3 - purinergic receptor P2X, ligand-gated ion channel, 3 Gene

P2rx3 - purinergic receptor P2X, ligand-gated ion channel, 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as P2X3; 4930513E20Rik

Gene ID: 228139 | Gene type: protein coding

About P2rx3

Chromosome 2: 84,828,927-84,867,806 reverse strand.GRCm39:CM000995.3

This gene has 5 transcripts (splice variants), 275 orthologues, 6 paralogues and is associated with 4 phenotypes. Biased expression in testis adult (RPKM 11.8), CNS E14 (RPKM 1.5) and 2 other tissues.

Summary

Enables extracellularly ATP-gated cation channel activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within several processes, including neuromuscular synaptic transmission; response to ATP; and smooth muscle contraction. Located in Schaffer collateral - CA1 synapse and axon. Is active in hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including branchial arch; embryo ectoderm; nervous system; retina; and skin. Orthologous to human P2RX3 (purinergic receptor P2X 3). [provided by Alliance of Genome Resources, Apr 2022]

P2rx3 Products(1)

mRNA Protein Name
NM_145526.2 NP_663501.2 P2X purinoceptor 3

P2rx3 Protein Structure

P2X_receptor

P2X_receptor: pfam00864 (7 - 359)

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  • 397 a.a.
Protein Preferred Names Protein Names

P2X purinoceptor 3

ATP receptor

purinergic receptor P2X3

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09903 P2RX3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09904 P2rx3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09905 P2rx3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P2rx3 NCBI NCBI:5024