2. Gene
  3. PPM1E - protein phosphatase, Mg2+/Mn2+ dependent 1E Gene

PPM1E - protein phosphatase, Mg2+/Mn2+ dependent 1E Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as POPX1; PP2CH; caMKN; CAMKPN; CaMKP-N

Gene ID: 22843 | Gene type: protein coding

About PPM1E

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,755,854-58,985,179 (from NCBI)

This gene has 1 transcript (splice variant), 207 orthologues and 16 paralogues. Biased expression in brain (RPKM 6.5), testis (RPKM 3.8) and 3 other tissues.

Summary

This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

PPM1E Products(1)

mRNA Protein Name
NM_014906.5 NP_055721.3 protein phosphatase 1E

PPM1E Protein Structure

PP2C

PP2C: Protein phosphatase 2C (233 - 481)

  • 0
  • 200
  • 400
  • 600
  • 755 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1E

ca(2+)/calmodulin-dependent protein kinase phosphatase N

Related Diseases

Diseases Alias
Mulibrey Nanism

MUL

Muscle-Liver-Brain-Eye Nanism

Pericardial Constriction And Growth Failure

Perheentupa Syndrome

Mulibrey Growth Disorder

Mulibrey Nanism Syndrome

Pericardial Constriction With Growth Failure

Nanism Mulibrey
Osteoblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10963 PPM1E Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PPM1E VGNC VGNC:33211
Rattus norvegicus PPM1E RGD RGD:735028
Felis catus PPM1E VGNC VGNC:99323
Macaca mulatta PPM1E VGNC VGNC:76073
Canis familiaris PPM1E VGNC VGNC:44865
Mus musculus PPM1E MGD MGI:2444096