NCBP2 - nuclear cap binding protein subunit 2 Gene

Homo sapiens

Also known as CBC2; NIP1; CBP20; PIG55

Gene ID: 22916 | Gene type: protein coding

About NCBP2

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:196,935,406-196,942,528 (from NCBI)

This gene has 13 transcripts (splice variants), 230 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 25.7), thyroid (RPKM 22.3) and 25 other tissues.

Summary

The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NCBP2 Products(4)

mRNA	Protein	Name
NM_001042540.2	NP_001036005.1	nuclear cap-binding protein subunit 2 isoform 2
NM_001308036.2	NP_001294965.1	nuclear cap-binding protein subunit 2 isoform 3
NM_001410857.1	NP_001397786.1	nuclear cap-binding protein subunit 2 isoform 4
NM_007362.5	NP_031388.2	nuclear cap-binding protein subunit 2 isoform 1

NCBP2 Protein Structure

RRM_1

0
100
156 a.a.

Protein Preferred Names

Protein Names

nuclear cap-binding protein subunit 2

20 kDa nuclear cap-binding protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09073	NCBP2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NCBP2	MGD	MGI:1915342
Felis catus	NCBP2	VGNC	VGNC:68424
Macaca mulatta	NCBP2	VGNC	VGNC:75139
Bos taurus	NCBP2	VGNC	VGNC:31908
Rattus norvegicus	NCBP2	RGD	RGD:1596188
Canis familiaris	NCBP2	VGNC	VGNC:43646

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