2. Gene
  3. SEPHS1 - selenophosphate synthetase 1 Gene

SEPHS1 - selenophosphate synthetase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SPS; SELD; SPS1

Gene ID: 22929 | Gene type: protein coding

About SEPHS1

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:13,317,428-13,348,293 (from NCBI)

This gene has 6 transcripts (splice variants), 227 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 16.5), kidney (RPKM 11.8) and 25 other tissues.

Summary

This gene encodes an Enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. [provided by RefSeq, Sep 2010]

SEPHS1 Products(4)

mRNA Protein Name
NM_001195602.2 NP_001182531.1 selenide, water dikinase 1 isoform 2
NM_001195604.2 NP_001182533.1 selenide, water dikinase 1 isoform 3
NM_001375769.1 NP_001362698.1 selenide, water dikinase 1 isoform 4
NM_012247.5 NP_036379.2 selenide, water dikinase 1 isoform 1

SEPHS1 Protein Structure

AIRS

AIRS: AIR synthase related protein, N-terminal domain (68 - 164)

AIRS_C

AIRS_C: AIR synthase related protein, C-terminal domain (193 - 367)

  • 0
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  • 392 a.a.
Protein Preferred Names Protein Names

selenide, water dikinase 1

selenium donor protein 1

Recombinant SEPHS1 Proteins

Cat. No. Product Name Accession Purity
HY-P71291 SEPHS1 Protein, Human (HEK293, His) P49903 (M1-S392) ≥95%

Related Diseases

Diseases Alias
Myopathy, Myosin Storage, Autosomal Dominant

MSMA

Myopathy, Hyaline Body, Autosomal Dominant

Myopathy With Lysis Of Type I Myofibrils

Autosomal Dominant Hyaline Body Myopathy

Hyaline Body Myopathy Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12678 SEPHS1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SEPHS1 VGNC VGNC:46009
Felis catus SEPHS1 VGNC VGNC:65007
Macaca mulatta SEPHS1 VGNC VGNC:103863
Rattus norvegicus SEPHS1 RGD RGD:1311182
Mus musculus SEPHS1 MGD MGI:1923580
Bos taurus SEPHS1 VGNC VGNC:34448
Others SEPHS1 NCBI