EXOSC7 - exosome component 7 Gene

Homo sapiens

Also known as p8; EAP1; RRP42; Rrp42p; hRrp42p

Gene ID: 23016 | Gene type: protein coding

About EXOSC7

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:44,976,244-45,012,668 (from NCBI)

This gene has 11 transcripts (splice variants), 204 orthologues and 2 paralogues. Ubiquitous expression in adrenal (RPKM 11.2), skin (RPKM 10.6) and 25 other tissues.

Summary

Predicted to enable 3'-5'-exoribonuclease activity and RNA binding activity. Predicted to be involved in RNA metabolic process. Part of exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]

EXOSC7 Products(1)

mRNA	Protein	Name
NM_015004.4	NP_055819.2	exosome complex component RRP42

EXOSC7 Protein Structure

RNase_PH

RNase_PH_C

0
100
200
291 a.a.

Protein Preferred Names

Protein Names

exosome complex component RRP42

exosome complex exonuclease RRP42

Related Diseases

Diseases

Alias

Pontocerebellar Hypoplasia, Type 1c

PCH1C	Hypomyelination With Spinal Muscular Atrophy And Cerebellar Hypoplasia
Pontocerebellar Hypoplasia Type 1c	Pontocerebellar Hypoplasia 1c
Doid:0112334	Hypoplasia, Pontocerebellar, Type 1c

Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome	Syndromic Diarrhea
Tricho-Hepato-Enteric Syndrome	Sd/The
Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome	THES1
Phenotypic Diarrhea	Thes
Phenotypic Diarrhea Of Infancy	Diarrhea, Syndromic
Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa	Intractable Diarrhea With Phenotypic Anomalies
Syndromatic Diarrhea	Fatal Infantile Diarrhea With Trichorrhexis Nodosa

Pontocerebellar Hypoplasia, Type 1b

Pontocerebellar Hypoplasia Type 1b	PCH1B
Pontocerebellar Hypoplasia 1b	Hypoplasia, Pontocerebellar, Type 1b

Pontocerebellar Hypoplasia, Type 1e

Pontocerebellar Hypoplasia Type 1	PCH1E
Norman Disease	Pch1
Pontocerebellar Hypoplasia With Anterior Horn Cell Disease	Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy
Pontocerebellar Hypoplasia Type 1e	Pontocerebellar Hypoplasia 1e
Doid:0112322	Doid:0112330

Trichohepatoenteric Syndrome 2

THES2

Pontocerebellar Hypoplasia

Pch	Congenital Pontocerebellar Hypoplasia
Opch	Hypoplasia, Pontocerebellar
Pontoneocerebellar Hypoplasia	Nonsyndromic Pontocerebellar Hypoplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04603	EXOSC7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EXOSC7	MGD	MGI:1913696
Macaca mulatta	EXOSC7	VGNC	VGNC:72383
Canis familiaris	EXOSC7	VGNC	VGNC:40527
Rattus norvegicus	EXOSC7	RGD	RGD:1309758
Felis catus	EXOSC7	VGNC	VGNC:62009
Bos taurus	EXOSC7	VGNC	VGNC:28661

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