PDZD2 - PDZ domain containing 2 Gene

Homo sapiens

Also known as AIPC; PIN1; PAPIN; PDZK3

Gene ID: 23037 | Gene type: protein coding

About PDZD2

Cytogenetic location: 5p13.3 Genomic coordinates (GRCh38): 5:31,639,131-32,110,932 (from NCBI)

This gene has 12 transcripts (splice variants), 230 orthologues and 1 paralogue. Biased expression in fat (RPKM 15.3), ovary (RPKM 9.0) and 12 other tissues.

Summary

The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a Caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. [provided by RefSeq, Dec 2015]

PDZD2 Products(1)

mRNA	Protein	Name
NM_178140.4	NP_835260.2	PDZ domain-containing protein 2

PDZD2 Protein Structure

PDZ

0
500
1000
1500
2000
2500
2839 a.a.

Protein Preferred Names

Protein Names

PDZ domain-containing protein 2

PDZ domain-containing protein 3

Related Diseases

Diseases

Alias

Motility-Related Diarrhea

Sacral Defect With Anterior Meningocele

Caudal Regression Syndrome	Caudal Regression Sequence
Sacral Agenesis	Caudal Dysgenesis Syndrome
SDAM	Caudal Dysplasia Sequence
Caudal Dysplasia	Sacral Agenesis Syndrome
Sacral Regression Syndrome	Sacral Defect And Anterior Sacral Meningocele
Rudd Klimek Syndrome	Sirenomelia

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10301	PDZD2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PDZD2	MGD	MGI:1922394
Bos taurus	PDZD2	VGNC	VGNC:32725
Rattus norvegicus	PDZD2	RGD	RGD:619958
Felis catus	PDZD2	VGNC	VGNC:64100
Macaca mulatta	PDZD2	VGNC	VGNC:75829

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