CMTR1 - cap methyltransferase 1 Gene

Homo sapiens

Also known as MTr1; hMTr1; FTSJD2; KIAA0082

Gene ID: 23070 | Gene type: protein coding

About CMTR1

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:37,423,985-37,481,508 (from NCBI)

This gene has 6 transcripts (splice variants), 200 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 31.1), spleen (RPKM 12.4) and 25 other tissues.

Summary

Enables mRNA (nucleoside-2'-O-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping and cap1 mRNA methylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CMTR1 Products(1)

mRNA	Protein	Name
NM_015050.3	NP_055865.1	cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

CMTR1 Protein Structure

G-patch

FtsJ

0
200
400
600
835 a.a.

Protein Preferred Names

Protein Names

cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

FtsJ methyltransferase domain containing 2

Related Diseases

Diseases

Alias

Vaccinia

Murray Valley Encephalitis

Australian Encephalitis	Australian X Disease
Encephalitis Australia	Murray River Encephalitis
Australian Arboencephalitis	Australian X Disorder
Mve - [Murray Valley Encephalitis]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02871	CMTR1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CMTR1	VGNC	VGNC:61004
Macaca mulatta	CMTR1	VGNC	VGNC:71271
Mus musculus	CMTR1	MGD	MGI:1921407
Bos taurus	CMTR1	VGNC	VGNC:27489
Rattus norvegicus	CMTR1	RGD	RGD:1307801
Canis familiaris	CMTR1	VGNC	VGNC:39385

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