PLXND1 - plexin D1 Gene

Homo sapiens

Also known as PLEXD1

Gene ID: 23129 | Gene type: protein coding

About PLXND1

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:129,555,214-129,606,676 (from NCBI)

This gene has 17 transcripts (splice variants), 191 orthologues, 8 paralogues and is associated with 4 phenotypes. Broad expression in placenta (RPKM 37.7), fat (RPKM 32.1) and 23 other tissues.

Summary

Enables protein domain specific binding activity. Predicted to be involved in several processes, including endothelial cell migration; nervous system development; and regulation of angiogenesis. Predicted to act upstream of or within several processes, including circulatory system development; dichotomous subdivision of terminal units involved in salivary gland branching; and positive regulation of protein binding activity. Located in lamellipodium. [provided by Alliance of Genome Resources, Apr 2022]

PLXND1 Products(1)

mRNA	Protein	Name
NM_015103.3	NP_055918.3	plexin-D1 precursor

PLXND1 Protein Structure

Sema

PSI

TIG

Plexin_cytopl

0
300
600
900
1200
1500
1800
1925 a.a.

Protein Preferred Names

Protein Names

plexin-D1

Related Diseases

Diseases

Alias

Moebius Syndrome

Mobius Syndrome	Moebius Sequence
Oromandibular-Limb Hypogenesis Spectrum	Congenital Facial Diplegia
MBS	Moebius Congenital Oculofacial Paralysis
Absence Or Underdevelopment Of The 6th And 7th Cranial Nerves	Congenital Facial Diplegia Syndrome
Congenital Oculofacial Paralysis	Congenital Ophthalmoplegia And Facial Paresis
Moebius Spectrum	Möbius Sequence
Möbius Syndrome	Mobius Ii Syndrome

Conotruncal Heart Malformations

Persistent Truncus Arteriosus	Conotruncal Anomaly Face Syndrome
Truncus Arteriosus	Common Arterial Trunk
CTHM	Conotruncal Heart Malformations, Variable
Tac	Truncus Arteriosus Communis
Conotruncal Cardiac Defects	Common Aorticopulmonary Trunk
Cafs	Conotruncal Heart Defects
Cthd	Dorv
Double-Outlet Right Ventricle	Pta
Heart Malformations, Conotruncal	Common Truncus
Common Truncus Arteriosus	Persistent Truncus Arteriosus Or Communis
Truncus Communis	Common Aortico-Pulmonary Trunk
Truncus Arteriosus With Aortic Dominance	Truncus Arteriosus With No Aortic Obstruction
Truncus Arteriosus With Pulmonary Dominance And Interrupted Aortic Arch	Truncus Arteriosus With Interrupted Aortic Arch
Common Arterial Trunk With Interrupted Aortic Arch	Van Praagh Truncus Arteriosus Type A4

Carey-Fineman-Ziter Syndrome 1

Carey-Fineman-Ziter Syndrome	CFZS
Congenital Nonprogressive Myopathy With Moebius And Robin Sequences	Myopathy, Congenital Nonprogressive, With Moebius Sequence And Robin Sequence
Cfz Syndrome	Carey Fineman Ziter Syndrome
Myopathy, Congenital Nonprogressive With Moebius And Robin Sequences	Myopathy-Moebius-Robin Syndrome
CFZS1	Moebius Sequence, Robin Complex, And Hypotonia
Congenital Non-Progressive Myopathy With Moebius And Robin Sequences

Spinocerebellar Ataxia 44

SCA44

Spondylocostal Dysostosis 1, Autosomal Recessive

Jarcho-Levin Syndrome	SCDO1
Vertebral Anomalies	Spondylothoracic Dysplasia
Costovertebral Dysplasia	Spondylothoracic Dysostosis
Spondylocostal Dysostosis 1	Autosomal Recessive Spondylocostal Dysostosis 1
Spondylocostal Dysostosis, Autosomal Recessive, 1	Doid:0112365
Dysostosis, Spondylocostal, Autosomal Recessive, Type 1

Congenital Fibrosis Of The Extraocular Muscles

Congenital Fibrosis Of Extraocular Muscles	Cfeom
Feom	Congenital External Ophthalmoplegia
Congenital Fibrosis Syndrome	General Fibrosis Syndrome

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10756	PLXND1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PLXND1	RGD	RGD:1310796
Macaca mulatta	PLXND1	VGNC	VGNC:76191
Bos taurus	PLXND1	VGNC	VGNC:33065
Canis familiaris	PLXND1	VGNC	VGNC:44726
Mus musculus	PLXND1	MGD	MGI:2154244
Felis catus	PLXND1	VGNC	VGNC:80659

Name
Email *

	Sorry, but the email address you supplied was invalid.