2. Gene
  3. EPB41L3 - erythrocyte membrane protein band 4.1 like 3 Gene

EPB41L3 - erythrocyte membrane protein band 4.1 like 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as 4.1B; DAL1; DAL-1

Gene ID: 23136 | Gene type: protein coding

About EPB41L3

Cytogenetic location: 18p11.31 Genomic coordinates (GRCh38): 18:5,392,386-5,630,663 (from NCBI)

This gene has 36 transcripts (splice variants), 289 orthologues and 10 paralogues. Broad expression in brain (RPKM 28.0), testis (RPKM 24.6) and 21 other tissues.

Summary

Predicted to enable cytoskeletal protein-membrane anchor activity. Predicted to be a structural constituent of Cytoskeleton. Predicted to be involved in several processes, including nervous system development; paranodal junction maintenance; and protein localization to paranode region of axon. Located in cell-cell junction and plasma membrane. Biomarker of meningioma. [provided by Alliance of Genome Resources, Apr 2022]

EPB41L3 Products(30)

mRNA Protein Name
NM_001281533.2 NP_001268462.1 band 4.1-like protein 3 isoform 2
NM_001281534.3 NP_001268463.1 band 4.1-like protein 3 isoform 3
NM_001281535.2 NP_001268464.1 band 4.1-like protein 3 isoform 4
NM_001330557.2 NP_001317486.1 band 4.1-like protein 3 isoform 5
NM_001384682.1 NP_001371611.1 band 4.1-like protein 3 isoform 2
NM_001384683.1 NP_001371612.1 band 4.1-like protein 3 isoform 4
NM_001384684.1 NP_001371613.1 band 4.1-like protein 3 isoform 5
NM_001384685.1 NP_001371614.1 band 4.1-like protein 3 isoform 6
NM_001384686.1 NP_001371615.1 band 4.1-like protein 3 isoform 7
NM_001384687.1 NP_001371616.1 band 4.1-like protein 3 isoform 8
NM_001384688.1 NP_001371617.1 band 4.1-like protein 3 isoform 8
NM_001384689.1 NP_001371618.1 band 4.1-like protein 3 isoform 9
NM_001384690.1 NP_001371619.1 band 4.1-like protein 3 isoform 9
NM_001384691.1 NP_001371620.1 band 4.1-like protein 3 isoform 10
NM_001384692.1 NP_001371621.1 band 4.1-like protein 3 isoform 11
NM_001384693.1 NP_001371622.1 band 4.1-like protein 3 isoform 12
NM_001384694.1 NP_001371623.1 band 4.1-like protein 3 isoform 13
NM_001384695.1 NP_001371624.1 band 4.1-like protein 3 isoform 14
NM_001384696.1 NP_001371625.1 band 4.1-like protein 3 isoform 15
NM_001384697.1 NP_001371626.1 band 4.1-like protein 3 isoform 16
NM_001384698.1 NP_001371627.1 band 4.1-like protein 3 isoform 17
NM_001384699.1 NP_001371628.1 band 4.1-like protein 3 isoform 18
NM_001384700.1 NP_001371629.1 band 4.1-like protein 3 isoform 19
NM_001384701.1 NP_001371630.1 band 4.1-like protein 3 isoform 20
NM_001384702.1 NP_001371631.1 band 4.1-like protein 3 isoform 21
NM_001384703.1 NP_001371632.1 band 4.1-like protein 3 isoform 22
NM_001384704.1 NP_001371633.1 band 4.1-like protein 3 isoform 23
NM_001384705.1 NP_001371634.1 band 4.1-like protein 3 isoform 24
NM_001384706.1 NP_001371635.1 band 4.1-like protein 3 isoform 25
NM_012307.5 NP_036439.2 band 4.1-like protein 3 isoform 1

EPB41L3 Protein Structure

FERM_N

FERM_N: FERM N-terminal domain (114 - 190)

FERM_M

FERM_M: FERM central domain (192 - 301)

FERM_C

FERM_C: FERM C-terminal PH-like domain (305 - 389)

FA

FA: FERM adjacent (FA) (397 - 443)

SAB

SAB: SAB domain (717 - 765)

4_1_CTD

4_1_CTD: 4.1 protein C-terminal domain (CTD) (968 - 1080)

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  • 1087 a.a.
Protein Preferred Names Protein Names

band 4.1-like protein 3

differentially expressed in adenocarcinoma of the lung protein 1

Related Diseases

Diseases Alias
Benign Meningioma

Meningioma, Benign
Acoustic Neuroma

Neurofibromatosis Type 2

Vestibular Schwannoma

Acoustic Neurinoma

Bilateral Acoustic Neurofibromatosis

Nf2

Acoustic Neurilemoma

Cerebellopontine Angle Tumor

Neurofibromatosis Central Type

Neurofibromatosis Type Ii

Vestibular Neurilemmoma

Acoustic Tumor

Neurinoma Of The Acoustic Nerve

Acoustic Neurinoma Bilateral

Acoustic Schwannomas Bilateral

Banf

Central Neurofibromatosis

Familial Acoustic Neuromas

Neurofibromatosis 2

Neurofibromatosis Type 2 Merlin

Schwannoma, Acoustic, Bilateral

Neuroma Acoustic

Neuroma, Acoustic

Familial Acoustic Neuroma

Familial Vestibular Schwannoma

Neurofibromatosis, Central Type

Nf2 - [Neurofibromatosis Type 2]
Bejel

Njovera

Dichuchwa

Nonvenereal Endemic Syphilis

Endemic Syphilis

Frenga

Nonvenereal Syphilis

Treponemal Infections

Non-Venereal Endemic Syphilis

Siti

Skerljevo

Belesh
Yaws

Frambesia

Frambesia Tropica

Bouba

Frambosie

Polypapilloma Tropicum

Thymosis

Endemic Treponematoses

Treponema Pertenue Infection

Pian

Framboesia

Framboesia Tropica

Castellani

Infection By Treponema Pertenue

Parangi

Framboesioma

Chancre Of Yaws

Primary Framboesia

Initial Lesions Of Yaws

Mother Yaw

Initial Framboesia
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
Adenocarcinoma

Adenocarcinomas

Adenoacanthoma Of Unspecified Site

Adenocarcinoid Of Unspecified Site

Adenocarcinoid Tumour Of Unspecified Site

Adenocarcinoma And Carcinoid Combined Of Unspecified Site

Adenocarcinoma Nos
Gummatous Syphilis
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Secondary Syphilis

Syphilis, Secondary

Secondary Syphilis Of Viscera Or Bone
Congenital Syphilis

Syphilis, Congenital

Congenital Syphilis, Unspecified

Mtct Of Syphilis

Mother-To-Child Transmission Of Syphilis

Syphilis Congenital

Hereditary Syphilis

Heredosyphilis
Osteogenesis Imperfecta, Type Xiii

Osteogenesis Imperfecta Type 13

OI13

Osteogenesis Imperfecta Type Xiii

Oi, Type Xiii

Osteogenesis Imperfecta 13

Oi Type Xiii

Oi-Xiii
Childhood Meningioma

Pediatric Meningioma
Primary Syphilis

Early Symptomatic Syphilis

Early Syphilis, Symptomatic

Symptomatic Early Syphilis
Neurofibromatosis, Type Ii

Neurofibromatosis 2

Neurofibromatosis, Type 2

NF2

Neurofibromatosis Type Ii

Bilateral Acoustic Neurofibromatosis

Banf

Acn

Central Neurofibromatosis

Neurofibromatosis, Central Type

Acoustic Schwannomas, Bilateral

Acoustic Neurinoma, Bilateral

Bilateral Acoustic Neurinoma

Bilateral Acoustic Schwannomas

Familial Acoustic Neuromas
Brain Cancer

Adult Brain Tumor

Malignant Neoplasm Of Brain

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04413 EPB41L3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus EPB41L3 VGNC VGNC:61894
Macaca mulatta EPB41L3 VGNC VGNC:72233
Bos taurus EPB41L3 VGNC VGNC:28522
Rattus norvegicus EPB41L3 RGD RGD:71089
Mus musculus EPB41L3 MGD MGI:103008
Canis familiaris EPB41L3 VGNC VGNC:40395