NCDN - neurochondrin Gene

Homo sapiens

Also known as NEDIES

Gene ID: 23154 | Gene type: protein coding

About NCDN

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:35,557,799-35,566,779 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues and is associated with 4 phenotypes. Biased expression in brain (RPKM 97.7), adrenal (RPKM 7.8) and 6 other tissues.

Summary

This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2008]

NCDN Products(3)

mRNA	Protein	Name
NM_001014839.2	NP_001014839.1	neurochondrin isoform 1
NM_001014841.2	NP_001014841.1	neurochondrin isoform 2
NM_014284.3	NP_055099.1	neurochondrin isoform 1

NCDN Protein Structure

Neurochondrin

0
200
400
600
729 a.a.

Protein Preferred Names

Protein Names

neurochondrin

norbin

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Infantile Epileptic Spasms

NEDIES

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Aceruloplasminemia

Cerebellar Ataxia	Hypoceruloplasminemia
Hemosiderosis, Systemic, Due To Aceruloplasminemia	Familial Apoceruloplasmin Deficiency
Hereditary Ceruloplasmin Deficiency	Deficiency Of Ferroxidase
Hypoceruloplasminemia, Hereditary	Ceruloplasmin Deficiency
Systemic Hemosiderosis Due To Aceruloplasminemia	ACERULOP

Autoimmune Neuropathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09075	NCDN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NCDN	VGNC	VGNC:31910
Felis catus	NCDN	VGNC	VGNC:63737
Macaca mulatta	NCDN	VGNC	VGNC:74980
Canis familiaris	NCDN	VGNC	VGNC:43648
Mus musculus	NCDN	MGD	MGI:1347351
Rattus norvegicus	NCDN	RGD	RGD:621734

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