2. Gene
  3. KAZN - kazrin, periplakin interacting protein Gene

KAZN - kazrin, periplakin interacting protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as KAZ; C1orf196

Gene ID: 23254 | Gene type: protein coding

About KAZN

Cytogenetic location: 1p36.21 Genomic coordinates (GRCh38): 1:13,892,824-15,118,043 (from NCBI)

This gene has 9 transcripts (splice variants) and 310 orthologues. Broad expression in spleen (RPKM 16.3), brain (RPKM 5.1) and 17 other tissues.

Summary

This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified. [provided by RefSeq, Aug 2011]

KAZN Products(8)

mRNA Protein Name
NM_001017999.3 NP_001017999.1 kazrin isoform C
NM_001018000.4 NP_001018000.1 kazrin isoform B
NM_001018001.3 NP_001018001.1 kazrin isoform C
NM_001370229.1 NP_001357158.1 kazrin isoform F
NM_001370230.1 NP_001357159.1 kazrin isoform G
NM_001370231.1 NP_001357160.1 kazrin isoform H
NM_015209.2 NP_056024.1 kazrin isoform A
NM_201628.3 NP_963922.2 kazrin isoform E

KAZN Protein Structure

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (444 - 508)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (530 - 583)

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (609 - 666)

  • 0
  • 200
  • 400
  • 600
  • 775 a.a.
Protein Preferred Names Protein Names

kazrin

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07090 KAZN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KAZN MGD MGI:1918779
Felis catus KAZN VGNC VGNC:107568
Bos taurus KAZN VGNC VGNC:30411
Rattus norvegicus KAZN RGD RGD:1359147
Canis familiaris KAZN VGNC VGNC:42221
Macaca mulatta KAZN VGNC VGNC:73932