MTCL1 - microtubule crosslinking factor 1 Gene

Homo sapiens

Also known as SOGA2; CCDC165; KIAA0802

Gene ID: 23255 | Gene type: protein coding

About MTCL1

Cytogenetic location: 18p11.22 Genomic coordinates (GRCh38): 18:8,705,556-8,832,778 (from NCBI)

This gene has 17 transcripts (splice variants), 216 orthologues and 2 paralogues. Broad expression in testis (RPKM 4.1), gall bladder (RPKM 3.9) and 22 other tissues.

Summary

Enables microtubule binding activity. Predicted to be involved in establishment or maintenance of epithelial cell apical/basal polarity; microtubule bundle formation; and positive regulation of protein targeting to membrane. Located in midbody and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]

MTCL1 Products(6)

mRNA	Protein	Name
NM_001378205.1	NP_001365134.1	microtubule cross-linking factor 1 isoform 1
NM_001378206.1	NP_001365135.1	microtubule cross-linking factor 1 isoform 2
NM_001378207.1	NP_001365136.1	microtubule cross-linking factor 1 isoform 3
NM_001395220.1	NP_001382149.1	microtubule cross-linking factor 1 isoform 5
NM_001395333.1	NP_001382262.1	microtubule cross-linking factor 1 isoform 6
NM_015210.4	NP_056025.2	microtubule cross-linking factor 1 isoform 4

MTCL1 Protein Structure

SOGA

DUF4482

0
300
600
900
1200
1500
1800
1905 a.a.

Protein Preferred Names

Protein Names

microtubule cross-linking factor 1

PAR-1-interacting protein

Related Diseases

Diseases

Alias

Cerebellar Ataxia Type 47

Sca47

Developmental And Epileptic Encephalopathy 28

DEE28	Epileptic Encephalopathy, Early Infantile, 28
Eiee28	Developmental And Epileptic Encephalopathy, 28
Early Infantile Epileptic Encephalopathy 28	Encephalopathy, Epileptic, Early Infantile, Type 28

Spinocerebellar Ataxia, Autosomal Recessive 12

Autosomal Recessive Spinocerebellar Ataxia 12	SCAR12
Spinocerebellar Ataxia With Mental Retardation And Epilepsy	Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Wwox Deficiency
Autosomal Recessive Spinocerebellar Ataxia Type 12	Spinocerebellar Ataxia, Autosomal Recessive, 12
Ataxia, Spinocerebellar, Autosomal Recessive, Type 12

Niemann-Pick Disease, Type C1

Niemann-Pick Disease, Type C	NPC1
Niemann-Pick Disease, Type D	Niemann-Pick Disease Type C1
Niemann-Pick Disease With Cholesterol Esterification Block	Niemann-Pick Disease, Subacute Juvenile Form
Neurovisceral Storage Disease With Vertical Supranuclear Ophthalmoplegia	Npc
Niemann-Pick Disease, Chronic Neuronopathic Form	Niemann-Pick Disease Without Sphingomyelinase Deficiency
Niemann-Pick Disease Type C	Niemann-Pick Disease Type D
Niemann-Pick C1 Disease	Niemann-Pick Disease C1
Niemann-Pick Disease Chronic Neuronopathic Form	Niemann-Pick Disease Nova Scotian Type
Niemann-Pick Disease Subacute Juvenile Form	Niemann-Pick Disease Type Ii
Niemann-Picks Disease Type C

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08756	MTCL1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MTCL1	RGD	RGD:1308319
Mus musculus	MTCL1	MGD	MGI:1915867
Felis catus	MTCL1	VGNC	VGNC:63642
Canis familiaris	MTCL1	VGNC	VGNC:43460
Macaca mulatta	MTCL1	VGNC	VGNC:74852
Bos taurus	MTCL1	VGNC	VGNC:31718

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