JADE2 - jade family PHD finger 2 Gene

Homo sapiens

Also known as PHF15; JADE-2

Gene ID: 23338 | Gene type: protein coding

About JADE2

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,523,952-134,583,227 (from NCBI)

This gene has 17 transcripts (splice variants), 212 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 11.1), ovary (RPKM 11.0) and 24 other tissues.

Summary

Predicted to enable ubiquitin protein ligase activity. Involved in histone acetylation. Located in nucleoplasm. Part of Histone Acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

JADE2 Products(8)

mRNA	Protein	Name
NM_001289984.2	NP_001276913.1	E3 ubiquitin-protein ligase Jade-2 isoform 1
NM_001289985.2	NP_001276914.1	E3 ubiquitin-protein ligase Jade-2 isoform 2
NM_001308143.2	NP_001295072.1	E3 ubiquitin-protein ligase Jade-2 isoform 4
NM_001388185.1	NP_001375114.1	E3 ubiquitin-protein ligase Jade-2 isoform 4
NM_001388186.1	NP_001375115.1	E3 ubiquitin-protein ligase Jade-2 isoform 4
NM_001388187.1	NP_001375116.1	E3 ubiquitin-protein ligase Jade-2 isoform 4
NM_001388188.1	NP_001375117.1	E3 ubiquitin-protein ligase Jade-2 isoform 5
NM_015288.6	NP_056103.4	E3 ubiquitin-protein ligase Jade-2 isoform 3

JADE2 Protein Structure

EPL1

PHD_2

zf-HC5HC2H_2

0
200
400
600
790 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase Jade-2

PHD finger protein 15

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07010	JADE2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	JADE2	VGNC	VGNC:73641
Bos taurus	JADE2	VGNC	VGNC:30359
Mus musculus	JADE2	MGD	MGI:1924151
Rattus norvegicus	JADE2	RGD	RGD:1309152
Felis catus	JADE2	VGNC	VGNC:62996
Canis familiaris	JADE2	VGNC	VGNC:42170

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