FNTA - farnesyltransferase, CAAX box, alpha Gene

Homo sapiens

Also known as FPTA; PTAR2; PGGT1A

Gene ID: 2339 | Gene type: protein coding

About FNTA

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:43,056,323-43,085,785 (from NCBI)

This gene has 14 transcripts (splice variants), 218 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 32.7), placenta (RPKM 27.4) and 25 other tissues.

Summary

Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]

FNTA Products(1)

mRNA	Protein	Name
NM_002027.3	NP_002018.1	protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

FNTA Protein Structure

PPTA

0
100
200
300
379 a.a.

Protein Preferred Names

Protein Names

protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

FTase-alpha

Related Diseases

Diseases

Alias

Dystonia 6, Torsion

DYT6	Torsion Dystonia 6
Dystonia 6	Idiopathic Torsion Dystonia Of Mixed Type
Primary Dystonia, Dyt6 Type	Torsion Dystonia, Adult-Onset, Mixed Type
Dyt-Thap1	Adolescent-Onset Dystonia Of Mixed Type
Torsion Dystonia Adult Onset Mixed Type	Dyt6 Dystonia
Thap1 Dystonia	Generalized Cervical And Upper-Limb-Onset Dystonia
Adult-Onset Torsion Dystonia Mixed Type	Autosomal Dominant Torsion Dystonia 6
Dystonia-6	Torsion Dystonia Type 6
Dystonia, Type 6, Torsion

Non-Functioning Pancreatic Endocrine Tumor

Non Functioning Pancreatic Endocrine Tumor	Non-Functioning Epts
Non-Functioning Endocrine Pancreatic Tumors

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05025	FNTA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FNTA	VGNC	VGNC:40937
Mus musculus	FNTA	MGD	MGI:104683
Felis catus	FNTA	VGNC	VGNC:62327
Bos taurus	FNTA	VGNC	VGNC:29070
Rattus norvegicus	FNTA	RGD	RGD:2625
Others	FNTA	NCBI