NCAPH - non-SMC condensin I complex subunit H Gene

Homo sapiens

Also known as CAPH; BRRN1; CAP-H; MCPH23

Gene ID: 23397 | Gene type: protein coding

About NCAPH

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:96,335,766-96,377,091 (from NCBI)

This gene has 7 transcripts (splice variants), 212 orthologues and is associated with 2 phenotypes. Biased expression in testis (RPKM 8.6), bone marrow (RPKM 4.4) and 11 other tissues.

Summary

This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2013]

NCAPH Products(4)

mRNA	Protein	Name
NM_001281710.2	NP_001268639.1	condensin complex subunit 2 isoform 2
NM_001281711.2	NP_001268640.1	condensin complex subunit 2 isoform 3
NM_001281712.2	NP_001268641.1	condensin complex subunit 2 isoform 4
NM_015341.5	NP_056156.2	condensin complex subunit 2 isoform 1

NCAPH Protein Structure

Cnd2

0
200
400
600
741 a.a.

Protein Preferred Names

Protein Names

condensin complex subunit 2

barren homolog 1

Related Diseases

Diseases

Alias

Microcephaly 23, Primary, Autosomal Recessive

MCPH23

Ovary Serous Adenocarcinoma

Malignant Ovarian Serous Tumor

Serous Carcinoma Of Ovary

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09070	NCAPH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09071	NCAPH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NCAPH	VGNC	VGNC:63734
Rattus norvegicus	NCAPH	RGD	RGD:1596799
Canis familiaris	NCAPH	VGNC	VGNC:43643
Bos taurus	NCAPH	VGNC	VGNC:31905
Mus musculus	NCAPH	MGD	MGI:2444777
Macaca mulatta	NCAPH	VGNC	VGNC:108147

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