FNTB - farnesyltransferase, CAAX box, beta Gene

Homo sapiens

Also known as FPTB

Gene ID: 2342 | Gene type: protein coding

About FNTB

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:64,986,895-65,062,650 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 9.3), brain (RPKM 8.2) and 25 other tissues.

Summary

Enables zinc ion binding activity. Contributes to protein farnesyltransferase activity. Involved in protein farnesylation. Part of microtubule associated complex and protein farnesyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

FNTB Products(1)

mRNA	Protein	Name
NM_002028.4	NP_002019.1	protein farnesyltransferase subunit beta

FNTB Protein Structure

SQHop_cyclase_N

Prenyltrans

0
100
200
300
400
437 a.a.

Protein Preferred Names

Protein Names

protein farnesyltransferase subunit beta

CAAX farnesyltransferase subunit beta

Related Diseases

Diseases

Alias

Myasthenic Syndrome, Congenital, 12

Congenital Myasthenic Syndrome 12	CMS12
Myasthenic Syndrome, Congenital, With Tubular Aggregates 1	Cmsta1
Myasthenia, Congenital, 12, With Tubular Aggregates	Congenital Myasthenia 12 With Tubular Aggregates
Limb-Girdle Myasthenia With Tubular Aggregates	Myasthenia, Congenital, With Tubular Aggregates 1
Myasthenic Syndrome, Congenital, With Tubular Aggregates, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05026	FNTB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FNTB	RGD	RGD:620119
Mus musculus	FNTB	MGD	MGI:1861305

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