CBLC - Cbl proto-oncogene C Gene

Homo sapiens

Also known as CBL-3; RNF57; CBL-SL

Gene ID: 23624 | Gene type: protein coding

About CBLC

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:44,777,869-44,800,652 (from NCBI)

This gene has 3 transcripts (splice variants), 95 orthologues, 2 paralogues and is associated with 60 phenotypes. Biased expression in duodenum (RPKM 19.1), small intestine (RPKM 14.9) and 11 other tissues.

Summary

This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

CBLC Products(2)

mRNA	Protein	Name
NM_001130852.1	NP_001124324.1	E3 ubiquitin-protein ligase CBL-C isoform 2
NM_012116.4	NP_036248.3	E3 ubiquitin-protein ligase CBL-C isoform 1

CBLC Protein Structure

Cbl_N

Cbl_N2

Cbl_N3

zf-C3HC4_3

0
100
200
300
400
474 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase CBL-C

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

Recombinant CBLC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74343	CBLC Protein, Human (sf9, His-GST)	Q9ULV8 (M1-A474)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107643	Reversan	Inhibitor	99.90%	Unkown
HY-154992	2,4-Difluorophenylethynylcobalamin		99.73%	Unkown
HY-RS01998	CBLC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CBLC	VGNC	VGNC:108489
Felis catus	CBLC	VGNC	VGNC:60422
Rattus norvegicus	CBLC	RGD	RGD:1307651
Canis familiaris	CBLC	VGNC	VGNC:38760
Bos taurus	CBLC	VGNC	VGNC:26810
Mus musculus	CBLC	MGD	MGI:1931457
Others	CBLC	NCBI

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