2. Gene
  3. Phgdh - 3-phosphoglycerate dehydrogenase Gene

Phgdh - 3-phosphoglycerate dehydrogenase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as A10; PGD; PGAD; PGDH; SERA; 3PGDH; 3-PGDH; 4930479N23

Gene ID: 236539 | Gene type: protein coding

About Phgdh

Chromosome 3: 98,220,486-98,247,306 reverse strand.GRCm39:CM000996.3

This gene has 4 transcripts (splice variants), 217 orthologues, 3 paralogues and is associated with 56 phenotypes. Broad expression in placenta adult (RPKM 138.), genital fat pad adult (RPKM 127.9) and 25 other tissues.

Summary

Predicted to enable phosphoglycerate dehydrogenase activity. Acts upstream of or within several processes, including G1 to G0 transition; cellular amino acid metabolic process; and nervous system development. Located in myelin sheath. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 1; PHGDH deficiency; and amino acid metabolic disorder. Orthologous to human PHGDH (phosphoglycerate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Phgdh Products(1)

mRNA Protein Name
NM_016966.3 NP_058662.2 D-3-phosphoglycerate dehydrogenase

Phgdh Protein Structure

PGDH_4

PGDH_4: cd12173 (7 - 309)

PGDH_inter

PGDH_inter: cl44735 (329 - 406)

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  • 533 a.a.
Protein Preferred Names Protein Names

D-3-phosphoglycerate dehydrogenase

3-phosphoglycerate dehyrogenase

Related Agents

Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101966 NCT-503 99.85% Unkown
HY-100012 CBR-5884 99.02% Unkown
HY-117240 NCT-502 99.18% Unkown
HY-126253 BI-4916 98.55% Unkown
HY-126254 BI-4924 99.55% Unkown
HY-123269 PKUMDL-WQ-2101 Inhibitor 99.85% Unkown
HY-121733 PHGDH-inactive 99.72% Unkown
HY-148570 PHGDH-IN-3 Inhibitor 98.99% Unkown
HY-123418 PKUMDL-WQ-2201 Inhibitor 98.72% Unkown
HY-145860 PHGDH-IN-2 / Unkown
HY-161456 PHGDH-IN-5 Inhibitor / Unkown
HY-RS10432 PHGDH Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10433 Phgdh Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10434 Phgdh Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-160252 PHGDH-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Phgdh NCBI NCBI:26227