2. Gene
  3. FLRT2 - fibronectin leucine rich transmembrane protein 2 Gene

FLRT2 - fibronectin leucine rich transmembrane protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 23768 | Gene type: protein coding

About FLRT2

Cytogenetic location: 14q31.3 Genomic coordinates (GRCh38): 14:85,530,144-85,654,428 (from NCBI)

This gene has 11 transcripts (splice variants), 252 orthologues and 22 paralogues. Ubiquitous expression in ovary (RPKM 6.8), brain (RPKM 2.7) and 21 other tissues.

Summary

This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

FLRT2 Products(5)

mRNA Protein Name
NM_001346143.2 NP_001333072.1 leucine-rich repeat transmembrane protein FLRT2 precursor
NM_001346144.2 NP_001333073.1 leucine-rich repeat transmembrane protein FLRT2 precursor
NM_001346145.2 NP_001333074.1 leucine-rich repeat transmembrane protein FLRT2 precursor
NM_001346146.2 NP_001333075.1 leucine-rich repeat transmembrane protein FLRT2 precursor
NM_013231.6 NP_037363.1 leucine-rich repeat transmembrane protein FLRT2 precursor

FLRT2 Protein Structure

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (35 - 62)

LRR_8

LRR_8: Leucine rich repeat (110 - 171)

LRR_8

LRR_8: Leucine rich repeat (182 - 242)

LRR_8

LRR_8: Leucine rich repeat (252 - 310)

fn3

fn3: Fibronectin type III domain (426 - 493)

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  • 660 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat transmembrane protein FLRT2

fibronectin-like domain-containing leucine-rich transmembrane protein 2

Recombinant FLRT2 Proteins

Cat. No. Product Name Accession Purity
HY-P70201 FLRT2 Protein, Human (HEK293, His) O43155 (C36-S539) ≥95%

Related Diseases

Diseases Alias
Glass Syndrome

Chromosome 2q32-Q33 Deletion Syndrome

Satb2-Associated Syndrome

2q33.1 Microdeletion Syndrome

Sas

2q32-Q33 Microdeletion Syndrome

2q32q33 Microdeletion Syndrome

Monosomy 2q32

Monosomy 2q32-Q33

Monosomy 2q32q33

2q32 Deletion Syndrome

Del(2)(Q32)

Del(2)(Q32q33)

GLASS

2q32q33 Microdeletion Syndromes

Satb2 Syndrome

Satb2-Associated Syndrome Due To A Chromosomal Rearrangement

Del(2)(Q33.1)

Monosomy 2q33.1

Satb2-Associated Syndrome Due To A Pathogenic Variant

Satb2-Associated Syndrome Due To A Point Mutation

Satb2 Associated Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04985 FLRT2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FLRT2 RGD RGD:1308574
Mus musculus FLRT2 MGD MGI:3603594
Felis catus FLRT2 VGNC VGNC:62297
Bos taurus FLRT2 VGNC VGNC:29039
Macaca mulatta FLRT2 VGNC VGNC:72676
Canis familiaris FLRT2 VGNC VGNC:40905
Others FLRT2 NCBI