MTCH1 - mitochondrial carrier 1 Gene

Homo sapiens

Also known as PSAP; PIG60; CGI-64; SLC25A49

Gene ID: 23787 | Gene type: protein coding

About MTCH1

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:36,968,135-36,986,551 (from NCBI)

This gene has 42 transcripts (splice variants), 187 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 127.6), brain (RPKM 84.7) and 25 other tissues.

Summary

This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the mitochondrion inner membrane and induces Apoptosis independent of the proapoptotic proteins Bax and Bak. Pseudogenes on chromosomes 6 and 11 have been identified for this gene. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Oct 2012]

MTCH1 Products(4)

mRNA	Protein	Name
NM_001271641.2	NP_001258570.1	mitochondrial carrier homolog 1 isoform PSAP-LL
NM_001410897.1	NP_001397826.1	mitochondrial carrier homolog 1 isoform 3
NM_001410899.1	NP_001397828.1	mitochondrial carrier homolog 1 isoform 4
NM_014341.2	NP_055156.1	mitochondrial carrier homolog 1 isoform PSAP-LS

MTCH1 Protein Structure

Mito_carr

0
100
200
300
389 a.a.

Protein Preferred Names

Protein Names

mitochondrial carrier homolog 1

cell proliferation-inducing protein 60

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 39

Hypomyelination, Global Cerebral	Agc1 Deficiency
Epileptic Encephalopathy, Early Infantile, 39	DEE39
Eiee39	Aspartate-Glutamate Carrier 1 Deficiency
Epileptic Encephalopathy With Global Cerebral Demyelination	Developmental And Epileptic Encephalopathy, 39
Early Infantile Epileptic Encephalopathy 39	Mitochondrial Aspartate-Glutamate Carrier 1 Deficiency
Global Cerebral Hypomyelination	Hereditary Central Nervous System Demyelinating Diseases

Hemoglobin E Disease

Hemoglobin E

Hb-E Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08754	MTCH1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MTCH1	VGNC	VGNC:55920
Rattus norvegicus	MTCH1	RGD	RGD:1309262
Mus musculus	MTCH1	MGD	MGI:1929261
Macaca mulatta	MTCH1	VGNC	VGNC:74788
Canis familiaris	MTCH1	VGNC	VGNC:43459
Felis catus	MTCH1	VGNC	VGNC:63641

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