2. Gene
  3. Comt - catechol-O-methyltransferase Gene

Comt - catechol-O-methyltransferase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 24267 | Gene type: protein coding

About Comt

Primary_assembly 11: 82,568,025-82,587,642 forward strand.mRatBN7.2:CM026984.1

This gene has 3 transcripts (splice variants), 276 orthologues, 2 paralogues and is associated with 68 phenotypes. Biased expression in Liver (RPKM 255.1), Kidney (RPKM 1227.4) and 5 other tissues.

Summary

Enables catechol O-methyltransferase activity. Involved in several processes, including learning or memory; negative regulation of smooth muscle cell proliferation; and regulation of cellular amine metabolic process. Located in several cellular components, including cell body; dendritic spine; and postsynaptic membrane. Used to study Parkinsonism and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autoimmune disease of skin and connective tissue (multiple); bulimia nervosa; cognitive disorder (multiple); and reproductive organ Cancer (multiple). Orthologous to human COMT (catechol-O-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Comt Products(1)

mRNA Protein Name
NM_012531.2 NP_036663.1 catechol O-methyltransferase

Comt Protein Structure

YrrM

YrrM: cl28097 (44 - 238)

  • 0
  • 100
  • 200
  • 265 a.a.
Protein Preferred Names Protein Names

catechol O-methyltransferase

catecholamine-O-methyltransferase

Related Agents

Approval
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17406 Tolcapone Inhibitor 99.91% Yes
HY-14280 Entacapone Inhibitor 99.92% Yes
HY-14896 Opicapone Inhibitor 99.06% Yes
HY-100562 Flopropione Inhibitor 98.57% Unkown
HY-14280R Entacapone (Standard) Inhibitor / Unkown
HY-14280A Entacapone sodium salt Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-N0529 Rosmarinic acid Inhibitor 99.70% Phase 4
HY-106405 Nebicapone Inhibitor 99.61% Phase 2
Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-133068 5-Hydroxyferulic acid 99.80% Unkown
HY-17406S1 Tolcapone-d4 Inhibitor 99.13% Unkown
HY-151388 hMAO-B/MB-COMT-IN-1 Inhibitor 98.04% Unkown
HY-14280S Entacapone-d10 Inhibitor ≥98.0% Unkown
HY-106842 Nitecapone Inhibitor 99.53% Unkown
HY-100642S 3-O-Methyltolcapone-d7 Inhibitor ≥99.0% Unkown
HY-133068A (E)-5-Hydroxyferulic acid / Unkown
HY-125339 Ro 41-0960 Inhibitor ≥98.0% Unkown
HY-100642 3-O-Methyltolcapone Inhibitor / Unkown
HY-17406S Tolcapone-d7 Inhibitor / Unkown
HY-151390 hMAO-B/MB-COMT-IN-2 Inhibitor / Unkown
HY-100642S1 3-O-Methyltolcapone-d4 Inhibitor / Unkown
HY-157719 S-Adenosylhomocysteine sulfoxide Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Comt NCBI NCBI:1312