EDNRA - endothelin receptor type A Gene

Rattus norvegicus

Also known as Eta; ET-A; ET-AR; Endor; RGD1559432

Gene ID: 24326 | Gene type: protein coding

About EDNRA

Primary_assembly 19: 30,233,571-30,297,049 forward strand.mRatBN7.2:CM026992.1

This gene has 5 transcripts (splice variants), 268 orthologues, 14 paralogues and is associated with 41 phenotypes. Biased expression in Lung (RPKM 125.), Heart (RPKM 74.4) and 7 other tissues.

Summary

Enables Endothelin Receptor activity. Involved in several processes, including cellular response to mechanical stimulus; glomerular filtration; and positive regulation of cytosolic calcium ion concentration. Located in T-tubule and nuclear membrane. Colocalizes with membrane raft. Used to study hypertension; myocardial infarction; portal hypertension; pulmonary emphysema; and pulmonary hypertension. Biomarker of several diseases, including hyperhomocysteinemia; impotence; obstructive sleep apnea; renal fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (Endothelin Receptor type A). [provided by Alliance of Genome Resources, Apr 2022]

EDNRA Products(1)

mRNA	Protein	Name
NM_012550.2	NP_036682.1	endothelin-1 receptor precursor

EDNRA Protein Structure

7tmA_ET-AR

0
100
200
300
400
426 a.a.

Protein Preferred Names

Protein Names

endothelin-1 receptor

endothelin A receptor

endothelin-1 receptor-like

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS04166	EDNRA Human Pre-designed siRNA Set A	/	Unkown
HY-RS04167	Ednra Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS04168	EDNRA Rat Pre-designed siRNA Set A	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990089	Patecibart	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	EDNRA	NCBI	NCBI:1909

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