2. Gene
  3. Nos1 - nitric oxide synthase 1 Gene

Nos1 - nitric oxide synthase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as bNOS

Gene ID: 24598 | Gene type: protein coding

About Nos1

Primary_assembly 12: 38,626,714-38,710,945 reverse strand.mRatBN7.2:CM026985.1

This gene has 3 transcripts (splice variants), 198 orthologues, 5 paralogues and is associated with 72 phenotypes. Biased expression in Adrenal (RPKM 54.3), Muscle (RPKM 48.6) and 4 other tissues.

Summary

Enables several functions, including ATPase binding activity; nucleotide binding activity; and transition metal ion binding activity. Involved in several processes, including blood vessel diameter maintenance; regulation of cation transmembrane transport; and regulation of neuron death. Located in several cellular components, including azurophil granule; nuclear membrane; and sarcolemma. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Used to study several diseases, including acute necrotizing pancreatitis; brain ischemia (multiple); end stage renal disease; impotence; and portal hypertension. Biomarker of several diseases, including brain disease (multiple); cardiomyopathy (multiple); hypertension (multiple); kidney failure (multiple); and retinal disease (multiple). Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; cystic fibrosis; and hypertrophic pyloric stenosis. Orthologous to human NOS1 (nitric oxide synthase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nos1 Products(1)

mRNA Protein Name
NM_052799.2 NP_434686.2 nitric oxide synthase, brain

Nos1 Protein Structure

PDZ_signaling

PDZ_signaling: cd00992 (14 - 97)

NOS_oxygenase_euk

NOS_oxygenase_euk: cd00795 (299 - 710)

Flavodoxin_1

Flavodoxin_1: pfam00258 (756 - 963)

Nitric_oxide_synthase

Nitric_oxide_synthase: cd06202 (1029 - 1432)

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  • 1532 a.a.
Protein Preferred Names Protein Names

nitric oxide synthase, brain

N-NOS

NC-NOS

NOS type I

constitutive NOS

nNOS

neuronal NOS

nitric oxidase synthase

nitric oxide synthase 1, neuronal

peptidyl-cysteine S-nitrosylase NOS1

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-18732A L-NMMA acetate Inhibitor 98.58% Phase 4
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N6607 Tryptanthrin 99.89% Unkown
HY-107720 ARL 17477 Inhibitor 99.02% Unkown
HY-12117 L-NIL hydrochloride Inhibitor / Unkown
HY-124996 (Rac)-ZLc-002 Inhibitor 98.96% Unkown
HY-130452 NOS1-IN-1 Inhibitor ≥95.0% Unkown
HY-RS09433 NOS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09434 Nos1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09435 Nos1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09436 NOS1AP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nos1 NCBI NCBI:4842