2. Gene
  3. PELI3 - pellino E3 ubiquitin protein ligase family member 3 Gene

PELI3 - pellino E3 ubiquitin protein ligase family member 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 246330 | Gene type: protein coding

About PELI3

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,466,327-66,477,337 (from NCBI)

This gene has 9 transcripts (splice variants), 179 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 6.1), ovary (RPKM 4.8) and 24 other tissues.

Summary

The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

PELI3 Products(4)

mRNA Protein Name
NM_001098510.2 NP_001091980.1 E3 ubiquitin-protein ligase pellino homolog 3 isoform 2
NM_001243135.2 NP_001230064.1 E3 ubiquitin-protein ligase pellino homolog 3 isoform 3
NM_001243136.2 NP_001230065.1 E3 ubiquitin-protein ligase pellino homolog 3 isoform 4
NM_145065.3 NP_659502.2 E3 ubiquitin-protein ligase pellino homolog 3 isoform 1

PELI3 Protein Structure

Pellino

Pellino: Pellino (76 - 469)

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  • 469 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase pellino homolog 3

RING-type E3 ubiquitin transferase pellino homolog 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10322 PELI3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PELI3 RGD RGD:1305989
Felis catus PELI3 VGNC VGNC:81961
Bos taurus PELI3 VGNC VGNC:32742
Macaca mulatta PELI3 VGNC VGNC:75886
Mus musculus PELI3 MGD MGI:1924963
Canis familiaris PELI3 VGNC VGNC:44416