2. Gene
  3. IL27 - interleukin 27 Gene

IL27 - interleukin 27 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as p28; IL30; IL-27; IL27A; IL-27A; IL27p28

Gene ID: 246778 | Gene type: protein coding

About IL27

Cytogenetic location: 16p12.1-p11.2 Genomic coordinates (GRCh38): 16:28,499,362-28,506,834 (from NCBI)

This gene has 2 transcripts (splice variants) and 88 orthologues. Biased expression in liver (RPKM 1.5), appendix (RPKM 0.4) and 6 other tissues.

Summary

The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]

IL27 Products(1)

mRNA Protein Name
NM_145659.3 NP_663634.2 interleukin-27 subunit alpha precursor
Protein Preferred Names Protein Names

interleukin-27 subunit alpha

IL-27 p28 subunit

Recombinant IL27 Proteins

Cat. No. Product Name Accession Purity
HY-P73199 IL-27 Protein, Human (CHO, His) Q14213 (R21-K229)&Q8NEV9 (F29-P243) ≥95%
HY-P77513 IL-27 Protein, Human (Biotinylated, CHO, His) Q14213 (M1-K229)&Q8NEV9 (F29-P243) ≥95%
HY-P700122AF Animal-Free IL-30/IL-27A Protein, Human (His) Q8NEV9 (F29-P243) ≥95%

Related Diseases

Diseases Alias
Toxoplasmosis

Disseminated Toxoplasmosis

Multisystemic Disseminated Toxoplasmosis

Acquired Toxoplasmosis

Toxoplasmosis Disease Or Disorder

Infection By Toxoplasma Gondii

Toxoplasmal

Toxoplasma
Autoimmune Disease Of Eyes, Ear, Nose And Throat
Autoimmune Uveitis
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990024 Casdozokitug Inhibitor 96.49% Phase 2
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-151508 Diamino lipid DAL4 / Unkown
HY-RS06746 IL27 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06747 IL27RA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus IL27 VGNC VGNC:62909
Rattus norvegicus IL27 RGD RGD:1561420
Canis familiaris IL27 VGNC VGNC:41976
Mus musculus IL27 MGD MGI:2384409
Macaca mulatta IL27 VGNC VGNC:99516
Bos taurus IL27 VGNC VGNC:30150
Others IL27 NCBI