2. Gene
  3. Ren - renin Gene

Ren - renin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Ren1; RENAA; RATRENAA

Gene ID: 24715 | Gene type: protein coding

About Ren

Primary_assembly 13: 44,796,091-44,807,489 forward strand.mRatBN7.2:CM026986.1

This gene has 3 transcripts (splice variants), 220 orthologues, 8 paralogues and is associated with 73 phenotypes. Restricted expression toward (RPKM 164.4).

Summary

Enables endopeptidase activity and insulin-like growth factor receptor binding activity. Involved in several processes, including peptide metabolic process; response to lipopolysaccharide; and response to purine-containing compound. Located in cytoplasm and extracellular space. Used to study hypertension. Biomarker of primary biliary cholangitis. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (Renin). [provided by Alliance of Genome Resources, Apr 2022]

Ren Products(1)

mRNA Protein Name
NM_012642.4 NP_036774.4 renin precursor

Ren Protein Structure

A1_Propeptide

A1_Propeptide: pfam07966 (30 - 63)

renin_like

renin_like: cd05487 (75 - 400)

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  • 402 a.a.
Protein Preferred Names Protein Names

renin

angiotensinogenase

renin 1 structural

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-112597A Mavodelpar Agonist 99.89% Phase 3
HY-112597 Mavodelpar free acid Agonist / Phase 3
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11839 REN Human Pre-designed siRNA Set A / Unkown
HY-RS11840 Ren Rat Pre-designed siRNA Set A / Unkown
HY-RS11841 Ren1 Mouse Pre-designed siRNA Set A / Unkown
HY-101724 ReN-1869 hydrochloride Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ren NCBI NCBI:5972
Felis catus Ren NCBI NCBI:101081695
Macaca fascicularis Ren NCBI NCBI:102122446
Canis lupus familiaris Ren NCBI
Mus musculus Ren NCBI
Susscrofa domestica Ren NCBI
Macaca mulatta Ren NCBI NCBI:574299