2. Gene
  3. NEIL2 - nei like DNA glycosylase 2 Gene

NEIL2 - nei like DNA glycosylase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NEH2; NEI2

Gene ID: 252969 | Gene type: protein coding

About NEIL2

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:11,769,710-11,787,345 (from NCBI)

This gene has 7 transcripts (splice variants), 114 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 14.3), brain (RPKM 9.4) and 24 other tissues.

Summary

This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This Enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This Enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]

NEIL2 Products(8)

mRNA Protein Name
NM_001135746.3 NP_001129218.1 endonuclease 8-like 2 isoform a
NM_001135747.3 NP_001129219.1 endonuclease 8-like 2 isoform b
NM_001135748.3 NP_001129220.1 endonuclease 8-like 2 isoform c
NM_001349439.2 NP_001336368.1 endonuclease 8-like 2 isoform b
NM_001349440.2 NP_001336369.1 endonuclease 8-like 2 isoform b
NM_001349441.2 NP_001336370.1 endonuclease 8-like 2 isoform b
NM_001349442.2 NP_001336371.1 endonuclease 8-like 2 isoform a
NM_145043.4 NP_659480.1 endonuclease 8-like 2 isoform a

NEIL2 Protein Structure

Fapy_DNA_glyco

Fapy_DNA_glyco: Formamidopyrimidine-DNA glycosylase N-terminal domain (2 - 180)

H2TH

H2TH: Formamidopyrimidine-DNA glycosylase H2TH domain (210 - 269)

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  • 300
  • 332 a.a.
Protein Preferred Names Protein Names

endonuclease 8-like 2

DNA glycosylase/AP lyase Neil2

Related Diseases

Diseases Alias
Autosomal Dominant Adult-Onset Proximal Spinal Muscular Atrophy

Autosomal Dominant Adult-Onset Proximal Sma

Autosomal Dominant Late-Onset Spinal Muscular Atrophy, Finkel Type

Finkel Disease

Smafk

Adult-Onset Proximal Spinal Muscular Atrophy, Autosomal Dominant

Autosomal Dominant Adult Proximal Spinal Muscular Atrophy

Finkel Late-Adult Type Sma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09188 NEIL2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NEIL2 MGD MGI:2686058
Bos taurus NEIL2 VGNC VGNC:31989
Canis familiaris NEIL2 VGNC VGNC:43727
Rattus norvegicus NEIL2 RGD RGD:1312033
Macaca mulatta NEIL2 VGNC VGNC:75210
Felis catus NEIL2 VGNC VGNC:107353